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Sucroferric oxyhydroxide

Generic name: sucroferric oxyhydroxide [ SOO-kroe-FER-ik-OX-ee-hye-DROX-ide ]
Brand name: Velphoro
Dosage form: oral tablet, chewable (2500 mg (500 mg elemental iron))
Drug class: Phosphate binders

Medically reviewed by on Jul 4, 2023. Written by Cerner Multum.

What is sucroferric oxyhydroxide?

Sucroferric oxyhydroxide is used to control phosphorus levels in people with chronic kidney disease who are on dialysis.

Sucroferric oxyhydroxide may also be used for purposes not listed in this medication guide.

Sucroferric oxyhydroxide side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a skin rash.

Common side effects of sucroferric oxyhydroxide may include:

  • diarrhea; or

  • darker color in your bowel movements.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

sucroferric oxyhydroxide is not approved for use by anyone younger than 18 years old.

How should I take sucroferric oxyhydroxide?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Sucroferric oxyhydroxide works best if you take it with meals.

The chewable tablet must be chewed or crushed before you swallow it.

You may need frequent blood tests.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking sucroferric oxyhydroxide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect sucroferric oxyhydroxide?

If you take levothyroxine: take it at least 4 hours before you take sucroferric oxyhydroxide.

If you take doxycycline, aspirin, or cephalexin: take it at least 1 hour before you take sucroferric oxyhydroxide.

Other drugs may affect sucroferric oxyhydroxide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.