Generic Name: sevelamer (se VEL a mer)
Brand Names: Renagel, Renvela
What is Renvela?
Renvela (sevelamer) is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus.
Renvela is used to control phosphorus levels in people with chronic kidney disease who are on dialysis.
Renvela may also be used for purposes not listed in this medication guide.
You should not take Renvela if you have a bowel obstruction.
Before taking Renvela, tell your doctor if you have severe constipation, a blockage in your intestines, a stomach or intestinal disorder, trouble swallowing, or if you have recently had stomach or intestinal surgery.
Avoid taking any other medicines within 1 hour before or 3 hours after you take Renvela. Sevelamer can bind to other medications and make them less effective.
Before taking this medicine, tell your doctor if you are taking ciprofloxacin (Cipro), a heart rhythm medication, or a seizure medication.
Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.
Before taking this medicine
You should not take Renvela if you are allergic to sevelamer, or if you have a bowel obstruction.
To make sure Renvela is safe for you, tell your doctor if you have:
a blockage in your intestines;
a stomach or intestinal disorder; or
if you have recently had stomach or intestinal surgery.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Your dose needs may be different during pregnancy.
It is not known whether sevelamer passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Renvela?
Take Renvela exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Take Renvela with meals.
Renvela powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water.
Stir the powder in water until it is completely dissolved. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
While using sevelamer, you may need frequent blood tests.
Call your doctor if you have have trouble swallowing the tablet, or if it feels like it gets stuck in your esophagus after you swallow it.
Renvela may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition.
Store at room temperature away from moisture and heat.
Renvela dosing information
Usual Adult Dose for Hyperphosphatemia of Renal Failure:
Initial Dosing for patients not on a phosphate binder: 800 mg to 1600 mg orally 3 times a day with meals
Based on serum phosphorus level:
-Phosphorus greater than 5.5 to less than 7.5 mg/dL: 800 mg 3 times a day with meals
-Phosphorus greater than or equal to 7.5 mg/dL: 1600 mg 3 times a day with meals
-Titrate in increments of 800 mg 3 times a day at 2-week intervals with the goal of controlling serum phosphorus within target range.
Average prescribed dose: 7.2 g/day (2.4 g with each meal)
Maximum studied dose: 14 g per day (carbonate); 13 g per day (hydrochloride)
Switching from the hydrochloride salt to carbonate: Use the same dose, however further titration may be necessary to achieve desired phosphorus levels.
Switching from calcium acetate: Substitute approximately mg for mg
Comment: Treatment of hyperphosphatemia includes reduction in dietary intake of phosphate, inhibition of intestinal phosphate absorption with phosphate binders, and removal of phosphate with dialysis.
Use: To control serum phosphorus levels in patients with chronic kidney disease on dialysis.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Be sure to take the missed dose with food. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Renvela?
You may be taking other medicines that should not be taken at the same time. Taking Renvela can make it harder for your body to absorb certain drugs, making them less effective:
ciprofloxacin (Cipro) should be taken at least 2 hours before or 6 hours after you take Renvela;
mycophenolate mofetil (CellCept) should be taken at least 2 hours before you take Renvela.
Renvela side effects
Get emergency medical help if you have signs of an allergic reaction to Renvela: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using Renvela and call your doctor at once if you have:
choking, or trouble swallowing;
black, bloody, or tarry stools;
severe constipation with stomach pain; or
constipation that gets worse or does not clear up.
Common Renvela side effects may include:
nausea, vomiting, stomach pain, loss of appetite;
upset stomach, gas, bloating;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Renvela?
Other drugs may interact with Renvela, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about Renvela (sevelamer)
- Other brands: Renagel
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Renvela.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2016 Cerner Multum, Inc. Version: 10.01. Revision Date: 2016-05-13, 9:43:46 AM.