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Generic name: mitapivat [ MYE-ta-PIV-at ]
Brand names: Pyrukynd, Pyrukynd Taper Pack
Dosage form: oral tablet (20 mg; 20 mg-5 mg; 5 mg; 50 mg; 50 mg-20 mg)
Drug class: Miscellaneous metabolic agents

Medically reviewed by on Nov 13, 2022. Written by Cerner Multum.

What is mitapivat?

Mitapivat is used to treat low red blood cell counts caused by hemolytic anemia (early breakdown of red blood cells) in adults with pyruvate kinase deficiency.

Mitapivat may also be used for purposes not listed in this medication guide.

Mitapivat side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mitapivat may cause serious side effects. Call your doctor at once if you have:

Common side effects of mitapivat may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Call your doctor at once if you have jaundice (yellowing of the skin or eyes), dark urine, dizziness, confusion, tiredness, or shortness of breath.

Before taking this medicine

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How should I take mitapivat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take mitapivat with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Do not share mitapivat with another person, even if they have the same symptoms you have.

Do not change your dose or stop using mitapivat without talking to your doctor. Your doctor will give you instructions for stopping mitapivat.

Store this medicine in the original container at room temperature.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking mitapivat?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect mitapivat?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect mitapivat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.