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Mitapivat Dosage

Medically reviewed by Last updated on Nov 13, 2022.

Applies to the following strengths: 5 mg; 20 mg; 50 mg; 20 mg-5 mg; 50 mg-20 mg

Usual Adult Dose for Hemolytic Anemia

Initial dose: 5 mg orally twice a day
Maintenance dose: 5 to 50 mg orally twice a day

Dose Titration Schedule:

Dose Taper Schedule:


Use: For the treatment of hemolytic anemia in patients with pyruvate kinase deficiency

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Moderate or severe liver dysfunction: Not recommended.

Dose Adjustments

For Adverse Reactions and Hemoglobin Levels Above Normal:

For Drug Interactions:



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.