Meloxicam and rizatriptan

Generic name: meloxicam and rizatriptan [ mel-OX-ikam-and-RYE-za-TRIP-tan ]
Brand name: Symbravo
Dosage form: oral tablet (20 mg-10 mg)
Drug class: Antimigraine agents

Medically reviewed by Drugs.com on Apr 15, 2025. Written by Cerner Multum.

What is meloxicam and rizatriptan?

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID). Rizatriptan is a migraine headache medicine.

Meloxicam and rizatriptan is a combination medicine used to treat migraine headaches with or without aura (warning signs appearing shortly before a migraine attack) in adults. meloxicam and rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Meloxicam and rizatriptan should not be used to treat cluster headaches or other types of migraines such as hemiplegic (causes loss of movement on one side of your body) and basilar (rare type of migraine with aura).

Meloxicam and rizatriptan may also be used for purposes not listed in this medication guide.

Meloxicam and rizatriptan side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop using meloxicam and rizatriptan and seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Stop taking this medicine and get emergency medical help if you have:

• signs of a heart attack or stroke--chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath;

• blood circulation problems in legs and feet--pain, weakness, numbness, tingling, color changes (pale or blue-colored appearance), cramps, burning, coldness, or heavy feeling in toes, feet, or legs.

• severe stomach and intestinal problems--sudden severe stomach pain (including after eating), weight loss, constipation, diarrhea, nausea, vomiting; or

• signs of serotonin syndrome--agitation, hallucinations, coma, fast heart rate, changes in blood pressure, high body temperature, muscle stiffness, trouble walking.

Meloxicam and rizatriptan may cause serious side effects. Stop using meloxicam and rizatriptan and call your doctor at once if you have:

• tiredness, shortness of breath;

• severe headache, blurred vision, problems with balance, confusion;

• heart problems--irregular heartbeats, high blood pressure, heart failure (swelling, rapid weight gain);

• kidney problems--swelling, urinating less;

• liver problems--loss of appetite, stomach pain (upper right side), itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), flu-like symptoms;

• low red blood cells (anemia)--pale skin, feeling light-headed, cold hands and feet; or

• stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Meloxicam and rizatriptan may worsen asthma attacks in people who have asthma. Talk with your doctor about your individual risk.

Common side effects of meloxicam and rizatriptan may include:

• dizziness, feeling tired;

• stomach pain, constipation, diarrhea; or

• gas, heartburn, nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

You should not use meloxicam and rizatriptan if you have or have ever had: heart problems, stroke, transient ischemic attack (TIA or "mini-stroke"), blood circulation problems, certain types of migraines, uncontrolled high blood pressure, moderate to severe kidney problems or on dialysis, or a history of severe allergic reaction to aspirin or an NSAID.

Meloxicam and rizatriptan can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Meloxicam and rizatriptan may also cause stomach or intestinal bleeding, which can be fatal.

Some drugs should not be used with meloxicam and rizatriptan. Your treatment plan may change if you also use: medications containing propranolol, other migraine headache medicine in the past 24 hours, certain antidepressants or have used them in the past 14 days.

Before taking this medicine

Meloxicam and rizatriptan can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Meloxicam and rizatriptan may also cause stomach or intestinal bleeding, which can be fatal. This can occur without warning, especially in older adults.

You should not use this medicine if you are allergic to meloxicam, rizatriptan or NSAIDs, or if you have:

• heart problems, uncontrolled high blood pressure;

• a history of stroke (including TIA or "mini-stroke");

• blood circulation problems (including poor blood flow to your arms and legs, stomach, or kidneys);

• a history of asthma or severe allergic reaction after taking aspirin or another NSAID;

• a headache that seems different from your usual migraine headaches; or

• moderate to severe kidney disease (or if you are on dialysis).

Do not use meloxicam and rizatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Do not take meloxicam and rizatriptan if you take medications containing propranolol.

Do not take this medicine within 24 hours before or after using another migraine headache medicine such as sumatriptan, almotriptan, zolmitriptan, dihydroergotamine, or methysergide.

Tell your doctor if you have or have ever had:

• heart problems, high blood pressure, chest pain, shortness of breath;

• risk factors for heart or blood vessel problems such as high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of heart problems, menopause, being over 40 and a man;

• asthma; or

• liver or kidney disease.

Do not use meloxicam and rizatriptan during pregnancy unless your doctor tells you to. Using an NSAID after 30 weeks of pregnancy can harm the unborn baby or cause pregnancy complications.

Ask a doctor if it is safe to breastfeed while using this medicine.

It may be harder for you to get pregnant while you are using this medicine.

How should I take meloxicam and rizatriptan?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Never use more than your recommended dose. Overuse of migraine medicine can make headaches worse.

Follow your doctor's dosing instructions very carefully. You may take meloxicam and rizatriptan with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Call your doctor if your headache symptoms do not improve, or if they get worse. You should not use this or other migraine medicine for 10 or more days per month.

Store meloxicam and rizatriptan in the original container at room temperature, away from moisture and heat.

Meloxicam and rizatriptan dosing information

Usual Adult Dose for Migraine:

Recommended dose: Meloxicam 20 mg-rizatriptan 10 mg (1 tablet) orally as needed for acute migraine
Maximum daily dose: Meloxicam 20 mg-rizatriptan 10 mg (1 tablet) orally as a single dose

Comments:
-It is recommended to use this drug for the shortest duration consistent with individual treatment goals.
-Safety/efficacy have not been established for administration of a second dose for the same migraine attack or for treating more than 7 headaches (on average) in a 30-day period.
-Ensure benefit outweighs risk if used in older adults; administer therapy for fewest total days per month.
-Limitations of use: Therapy should only be used when a clear diagnosis of migraine has been established. If a patient has no response after treatment for the first migraine attack, reconsider diagnosis prior to using this drug to treat any subsequent attacks.
-Therapy is not indicated for the preventive treatment of migraine attacks or for the treatment of cluster headache.

Use: For the acute treatment of migraine with or without aura

What happens if I miss a dose?

Meloxicam and rizatriptan is used when needed and does not have a daily dosing schedule. Call your doctor if the medicine is not effective.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking meloxicam and rizatriptan?

Drinking alcohol may increase your risk of stomach bleeding.

Avoid driving or hazardous activity until you know how meloxicam and rizatriptan will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to meloxicam (such as aspirin, ibuprofen, ketoprofen, or naproxen).

What other drugs will affect meloxicam and rizatriptan?

Ask your doctor before taking meloxicam and rizatriptan if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your other medicines, especially:

• cyclosporine, lithium, methotrexate, pemetrexed;

• heart or blood pressure medicine, including a diuretic or "water pill";

• propranolol;

• NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or

• a blood thinner--warfarin, Coumadin, Jantoven.

This list is not complete. Other drugs may affect meloxicam and rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2025 Cerner Multum, Inc. Version: 1.01.