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Estropipate

Generic name: estropipate [ ES-troe-PIP-ate ]
Brand names: Ogen 1.25, Ortho-Est, Ogen 0.625, Ogen 2.5
Dosage form: oral tablet (0.75 mg; 1.5 mg)
Drug class: Estrogens

Medically reviewed by Drugs.com on Aug 4, 2023. Written by Cerner Multum.

What is estropipate?

Estropipate is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estropipate is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Estropipate is also used to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

Estropipate may also be used for purposes not listed in this medication guide.

Estropipate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Estropipate may cause serious side effects. Call your doctor at once if you have:

Common side effects of estropipate may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use estropipate if you have: undiagnosed vaginal bleeding, liver disease, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Estropipate may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using estropipate can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estropipate should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not use estropipate if you are allergic to it, or if you have:

Do not use estropipate if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Using estropipate can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Estropipate should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

Tell your doctor if you have ever had:

Using estropipate may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.

Estropipate can slow breast milk production. Tell your doctor if you are breast-feeding.

How should I use estropipate?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Estropipate may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estropipate.

If you need major surgery or will be on long-term bed rest, you may need to stop using estropipate for a short time. Any doctor or surgeon who treats you should know that you are using estropipate.

Store this medication at room temperature away from moisture and heat.

alendronate, estradiol, Fosamax, Prolia, calcium carbonate, Premarin, Estrace, Tymlos, Vagifem, conjugated estrogens

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using estropipate?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estropipate.

Grapefruit may interact with estropipate and lead to unwanted side effects. Avoid the use of grapefruit products.

What other drugs will affect estropipate?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect estropipate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does estropipate interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.