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Entocort EC

Generic name: budesonide (oral) [ bue-DES-oh-nide ]
Brand names: Entocort EC, Ortikos, Tarpeyo, Uceris
Drug class: Glucocorticoids

Medically reviewed by on Mar 29, 2023. Written by Cerner Multum.

What is Entocort EC?

Entocort and Ortikos are used to treat mild to moderate Crohn's disease in adults and children at least 8 years old who weigh 55 pounds (25 kg) or more. These medicines are also used in adults for up to 3 months to keep symptoms from returning.

Uceris is used to treat mild to moderate ulcerative colitis (UC) in adults.

Tarpeyo is used to lower levels of protein in the urine (proteinuria) in adults with a kidney disease called primary immunoglobulin A nephropathy.

Entocort EC may also be used for purposes not listed in this medication guide.


Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use Entocort EC if you are allergic to it.

Tell your doctor if you have or ever had:

Steroids can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have. Tell your doctor about any illness or infection you had within the past several weeks.

Tell your doctor if you are pregnant or plan to become pregnant, or breastfeeding or plan to breastfeed.

Do not use Entocort EC in a child to treat any condition that has not been checked by your doctor.

How should I take Entocort EC?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take Entocort EC in the morning with a full glass of water. You may take this medicine with or without food.

Take Tarpeyo in the morning, at least 1 hour before a meal.

You should not stop using Entocort EC suddenly. Follow your doctor's instructions about tapering your dose.

Do not stop using Tarpeyo without your doctor's advice. Tell your doctor if your medicine seems to stop working.

Do not crush, break, or dissolve a tablet or capsule of Uceris, Tarpeyo, or Ortikos. Swallow it whole.

If you cannot swallow an Entocort capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing, then drink a full glass of water.

Your dosage needs may change if you have surgery, are ill, or are under stress. Do not change your doses or medication schedule without advice from your doctor.

If you take Entocort EC long-term, you may need frequent medical tests.

Call your doctor if your symptoms do not improve, or if they get worse.

Store tightly closed at room temperature, away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

High doses or long-term use of steroid medicine can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while taking Entocort EC?

Grapefruit may interact with Entocort EC and cause side effects. Avoid consuming grapefruit products.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Entocort EC.

Entocort EC side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Entocort EC may cause serious side effects. Call your doctor at once if you have:

  • increased adrenal gland hormones--hunger, weight gain, swelling, skin discoloration, slow wound healing, sweating, acne, increased body hair, tiredness, mood changes, muscle weakness, missed menstrual periods, sexual changes;

  • decreased adrenal gland hormones--nausea, vomiting, stomach pain, loss of appetite, feeling tired or light-headed, muscle or joint pain, skin discoloration, craving salty foods; or

  • signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding.

Entocort EC can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Entocort EC.

Common side effects of Entocort EC may include:

  • headache, dizziness;

  • indigestion, nausea, vomiting, stomach pain, bloating, gas, constipation;

  • feeling tired;

  • high blood pressure;

  • back pain, muscle cramps, joint pain;

  • swelling of the face, lower legs, ankles, and feet;

  • pain and burning when you urinate;

  • acne;

  • thicker or increased hair on your body and face;

  • cold symptoms such as stuffy nose, sneezing, sore throat; or

  • decreased adrenal gland hormones.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Entocort EC?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Ask a doctor or pharmacist before using Entocort EC with any other medicines, especially:

  • stomach acid reducers.

This list is not complete. Other drugs may affect Entocort EC, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.