Skip to main content

Drospirenone and estradiol

Generic name: drospirenone and estradiol [ droe-SPYE-re-none-and-ES-tra-DYE-ole ]
Brand name: Angeliq
Dosage form: oral tablet (0.25 mg-0.5 mg; 0.5 mg-1 mg)
Drug class: Sex hormone combinations

Medically reviewed by Drugs.com on Aug 27, 2024. Written by Cerner Multum.

What is drospirenone and estradiol?

Drospirenone is a female hormone that helps regulate ovulation and menstruation.

Estradiol is a female hormone involved in development and maintenance of the female reproductive system.

Drospirenone and estradiol is a combination medicine used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. drospirenone and estradiol is for use only if you have a uterus (if you have not had a hysterectomy).

Drospirenone and estradiol may also be used for purposes not listed in this medication guide.

Drospirenone and estradiol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Drospirenone and estradiol may cause serious side effects. Call your doctor at once if you have:

Common side effects of drospirenone and estradiol may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use drospirenone and estradiol if you have: undiagnosed vaginal bleeding, coronary artery disease, a bleeding disorder, kidney disease, liver disease, an adrenal gland disorder, if you will have major surgery, if you have had a hysterectomy, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Drospirenone and estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Taking this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Drospirenone and estradiol should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not use this medicine if you are allergic to drospirenone or estradiol, or if you have:

Do not use drospirenone and estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Taking this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Drospirenone and estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

Tell your doctor if you have ever had:

Using drospirenone and estradiol may increase your risk of breast cancer. Talk with your doctor about your risk before using this medicine long term.

This medicine lowers the hormone needed to produce breast milk and can slow breast milk production. You should not breast-feed while taking drospirenone and estradiol.

How should I take drospirenone and estradiol?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not crush, chew, break, or dissolve a drospirenone and estradiol tablet. Swallow it whole.

Take drospirenone and estradiol at the same time each day.

Drospirenone and estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk. Report any unusual vaginal bleeding right away.

If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using drospirenone and estradiol.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using this medicine.

Store at room temperature away from moisture and heat.

Drospirenone and estradiol dosing information

Usual Adult Dose for Postmenopausal Symptoms:

Vasomotor symptoms:
One 0.25 mg drospirenone/0.5 mg estradiol tablet orally once a day
OR
One 0.5 mg drospirenone/1 mg estradiol tablet orally once a day

Vulvar and vaginal atrophy:
One 0.5 mg drospirenone/1 mg estradiol tablet orally once a day


Comments:
-Treatment is continuous.
-Women not on estrogens, or those on a continuous combination product may start treatment anytime.
-Women switching from continuous sequential or cyclic hormone therapy should complete their current cycle before switching.
-When used solely for vulvar and vaginal atrophy, consider using topical vaginal products.

Uses: Treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause

estradiol, Premarin, Estrace, conjugated estrogens

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while taking drospirenone and estradiol?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using drospirenone and estradiol.

Grapefruit may interact with drospirenone and estradiol and lead to unwanted side effects. Avoid the use of grapefruit products.

What other drugs will affect drospirenone and estradiol?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect drospirenone and estradiol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does drospirenone/estradiol interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.