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Drospirenone / estradiol Side Effects

For the Consumer

Applies to drospirenone / estradiol: oral tablet

In addition to its needed effects, some unwanted effects may be caused by drospirenone / estradiol. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking drospirenone / estradiol:

More common:
  • Breast pain
  • full or bloated feeling
  • heavy non-menstrual vaginal bleeding
  • pressure in the stomach
  • surgery
  • swelling of the abdominal or stomach area
Less common:
  • Bloating or swelling of the face, arms, hands, legs, or feet
  • change in vaginal discharge
  • increased clear or white vaginal discharge
  • pain or feeling of pressure in the pelvis
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
  • vaginal bleeding
Incidence not known:
  • Abdominal or stomach pain
  • anxiety
  • blurred vision
  • change in vision
  • chest pain or discomfort
  • clear or bloody discharge from nipple
  • confusion
  • constipation
  • cough
  • coughing up blood
  • depression
  • difficulty with speaking
  • dimpling of the breast skin
  • dizziness or lightheadedness
  • double vision
  • dry mouth
  • fainting
  • fast heartbeat
  • headache
  • headache, severe and throbbing
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • incoherent speech
  • increased urination
  • inverted nipple
  • loss of appetite
  • lump in the breast or under the arm
  • metallic taste
  • muscle weakness
  • nausea and vomiting
  • numbness or weakness in your arm or leg, or on one side of your body
  • pain or discomfort in the arms, jaw, back, or neck
  • pain or redness in your lower leg (calf)
  • persistent crusting or scaling of the nipple
  • poor insight and judgment
  • problems with memory, vision, speech, or walking
  • redness or swelling of the breast
  • seeing double
  • shortness of breath
  • slow speech
  • sore on the skin of the breast that does not heal
  • sudden or severe headache
  • sudden shortness of breath or troubled breathing
  • sweating
  • thirst
  • trouble recognizing objects
  • trouble thinking and planning
  • trouble walking
  • unusual tiredness or weakness
  • weight loss

Minor Side Effects

Some of the side effects that can occur with drospirenone / estradiol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Accidental injury
  • back pain
  • body aches or pain
  • chills
  • diarrhea
  • difficulty breathing
  • ear congestion
  • fever, sneezing, or sore throat
  • general feeling of discomfort or illness
  • joint pain
  • loss of voice
  • muscle aches and pains
  • pain in the arms or legs
  • pain or tenderness around the eyes and cheekbones
  • runny nose
  • shivering
  • stuffy or runny nose
  • sweating
  • tightness of the chest or wheezing
  • trouble sleeping

For Healthcare Professionals

Applies to drospirenone / estradiol: oral tablet


Cardiovascular side effects have included deep and superficial venous thrombosis, pulmonary embolism, thrombophlebitis, myocardial infarction, stroke and increased blood pressure.[Ref]


Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, bloating, cholestatic jaundice, increased incidence of gall bladder disease, pancreatitis, abdominal pain, enlarged abdomen, and enlargement of hepatic hemangiomas.[Ref]


Dermatologic side effects have included chloasma or melasma, erythema multiforme, erythema nodosum, hemorrhagic resumption, loss of scalp hair, hirsutism, pruritus, and rash.[Ref]

Nervous system

Nervous system side effects have included headache, migraine, dizziness, mental depression, chorea, nervousness, mood disturbances, irritability, exacerbation of epilepsy and dementia.[Ref]


Ocular side effects have included retinal vascular thrombosis and intolerance to contact lenses.[Ref]


Genitourinary side effects have included breast tenderness, pain and enlargement, nipple discharge, galactorrhea, fibrocystic breast disease, breast cancer, vaginal hemorrhage, endometrial disorder, leukorrhea, breast pain, increase in size of leiomyomata, vaginitis, changes in vaginal bleeding pattern, abnormal withdrawal bleeding or flow, breakthrough bleeding, spotting, dysmenorrhea, vaginal candidiasis, change in amount of cervical secretion, changes in cervical ectropion, ovarian cancer, endometrial hyperplasia, and endometrial cancer.[Ref]


Hypersensitivity side effects have included anaphylactic reactions including urticaria and angioedema.[Ref]


Endocrine side effects have included reduced carbohydrate tolerance, hypocalcemia, and increased triglycerides.[Ref]


Respiratory side effects have included upper respiratory infection, sinusitis, and exacerbation of asthma.[Ref]


General side effects have included increase or decrease in weight, edema, flu syndrome, accidental injury, surgery, pain in extremity, and changes in libido.[Ref]


Metabolic side effects have included aggravation of porphyria.[Ref]


Musculoskeletal side effects have included arthralgias, back pain and leg cramps[Ref]


1. "Product Information. Angeliq (drospirenone-estradiol)." Berlex Laboratories, Wayne, NJ.

Not all side effects for drospirenone / estradiol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.