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Generic Name: testosterone injection (tes TOS ter one)
Brand Name: Aveed, Delatestryl, Depo-Testosterone, Testosterone Cypionate, Testosterone Enanthate

Medically reviewed by on Nov 5, 2018 – Written by Cerner Multum

What is Depo-Testosterone?

Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system.

Depo-Testosterone is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty, impotence, or other hormonal imbalances.

Depo-Testosterone is also used in women to treat breast cancer that has spread to other parts of the body.

Testosterone will not enhance athletic performance and should not be used for that purpose.

Depo-Testosterone may also be used for purposes not listed in this medication guide.

Important Information

Do not use Depo-Testosterone if you are pregnant or may become pregnant.

You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease.

Misuse of testosterone can cause dangerous or irreversible effects. Depo-Testosterones should be given only by a healthcare professional.

Before taking this medicine

You should not receive testosterone if you are allergic to it, or if you have:

  • prostate cancer;

  • male breast cancer;

  • a serious heart condition;

  • severe liver disease;

  • severe kidney disease; or

  • if you are pregnant or may become pregnant.

To make sure testosterone is safe for you, tell your doctor if you have:

This medicine can harm an unborn baby or cause birth defects. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving testosterone.

It is not known whether testosterone injection passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Depo-Testosterone given?

Testosterone is injected into a muscle. Depo-Testosterone is usually given every 2 to 4 weeks.

Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence.

Depo-Testosterones should be given only by a healthcare professional.

The length of treatment with Depo-Testosterone will depend on the condition being treated.

Testosterone will not enhance athletic performance and should not be used for that purpose.

While receiving testosterone, you will need frequent blood tests.

Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Depo-Testosterone.

What happens if I overdose?

Since Depo-Testosterone is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Depo-Testosterone?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Depo-Testosterone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • nausea or vomiting;

  • changes in skin color;

  • increased or ongoing erection of the penis;

  • impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size;

  • painful or difficult urination;

  • shortness of breath (even with mild exertion);

  • chest pain or pressure, pain spreading to your jaw or shoulder;

  • swelling in your ankles or feet, rapid weight gain;

  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;

  • high levels of calcium in the blood--stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or

  • liver problems--upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone:

  • acne;

  • changes in menstrual periods;

  • male-pattern hair growth (such as on the chin or chest);

  • hoarse or deepened voice; or

  • enlarged clitoris.

Common side effects (in men or women) may include:

  • breast swelling;

  • headache, anxiety;

  • increased facial or body hair growth, male-pattern baldness;

  • increased or decreased interest in sex;

  • numbness or tingly feeling; or

  • pain or swelling where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Depo-Testosterone?

Other drugs may interact with testosterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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