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Xyosted Injection

Generic name: testosterone injectiontes-TOS-ter-one ]
Brand name: Xyosted
Drug class: Androgens and anabolic steroids

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 28, 2022.

What is Xyosted?

Xyosted injection is a single-dose syringe supplied as an autoinjector containing testosterone. Testosterone is a naturally occurring sex hormone produced in a man's testicles.

Xyosted is a prescription medicine used as a hormone replacement therapy in adult men who have low or no testosterone due to certain medical conditions.

Xyosted will not enhance athletic performance and should not be used for that purpose.

It is not known if Xyosted is safe or effective in children younger than 18 years old. Improper use of testosterone may affect bone growth in children.


You should not be treated with Xyosted if you have prostate cancer, male breast cancer, a serious heart condition, severe liver or kidney disease, or an allergy to castor oil or sesame oil.

Xyosted is not for use in treating low testosterone without certain medical conditions or due to getting older. Testosterone should not be used to enhance athletic performance.

Xyosted is not for use in women.

Testosterone can increase your risk of heart attack, stroke, or death. You may need to stop using Xyosted or start taking blood pressure medication.

Misuse of testosterone can cause dangerous or irreversible effects. Do not share this medicine with another person.

Before taking this medicine

You should not be treated with Xyosted if you are allergic to testosterone, or if you have:

Xyosted is not for use in women. This medicine can harm an unborn baby.

To make sure Xyosted is safe for you, tell your doctor if you have ever had:

Using Xyosted may increase your risk of developing prostate cancer, liver problems, or heart problems (including heart attack, stroke, or death). Ask your doctor about these risks.

Xyosted should not be given to a child younger than 12 years old. Some types of this medicine are not approved for use by anyone younger than 18 years old.

How is Xyosted given?

Xyosted is injected under the skin or into a muscle, usually given every 2 to 4 weeks. Xyosteds should be given only by a healthcare professional.

Testosterone can raise your blood pressure, which could increase your risk of heart attack, stroke, or death. Your blood pressure will need to be checked often. You may need to stop using Xyosted or start taking blood pressure medication.

You will need frequent blood tests.

Testosterone can affect the results of certain medical tests. Tell any doctor who treats you that you are using Xyosted.

Misuse of Xyosted can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Stealing, selling, or giving away this medicine is against the law.

If you have used too much Xyosted, stopping the medicine may caused unpleasant withdrawal symptoms, such as depression, tiredness, irritability, loss of appetite, sleep problems, or decreased libido.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Xyosted.

What happens if I overdose?

Since Xyosted is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Xyosted?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Xyosted side effects

Get emergency medical help if you have signs of an allergic reaction to Xyosted: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have a tight feeling in your throat, a sudden urge to cough, or if you feel light-headed or short of breath during or shortly after receiving the injection.

You will be watched closely for at least 30 minutes to make sure you do not have a reaction to the injection.

Call your doctor at once if you have:

Your Xyosteds may be delayed or permanently discontinued if you have certain side effects.

Common Xyosted side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xyosted?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with testosterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Xyosted contains tesosterone, which is a Schedule 3 controlled substance in the US, according to the Controlled Substances Act. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xyosted only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.