Delgocitinib topical

Generic name: delgocitinib topical [ DEL-goe-SYE-ti-nib ]
Brand name: Anzupgo
Dosage form: topical cream (2%)
Drug class: Miscellaneous topical agents

Medically reviewed by Drugs.com on Sep 18, 2025. Written by Cerner Multum.

What is delgocitinib topical?

Delgocitinib topical (for the skin) is used in adults to treat moderate to severe chronic eczema (atopic dermatitis) affecting the hands.

Delgocitinib topical is given after other treatments are not recommended, did not work, or stopped working

Delgocitinib topical may also be used for purposes not listed in this medication guide.

Delgocitinib topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Delgocitinib topical may cause serious side effects. Call your doctor at once if you have:

• heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

• signs of a blood clot--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, problems with vision or balance, chest pain, sudden cough or shortness of breath, dizziness, coughing up blood, pain, swelling, or warmth in one leg;

• signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding;

• signs of tuberculosis--fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired; or

• signs of shingles or eczema herpeticum--flu-like symptoms, painful blistering rash.

Common side effects of delgocitinib topical may include:

• pain, tingling, itching, or redness in the area of the skin where the medicine was applied;

• skin and nail infections; or

• low white blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

Before you start using delgocitinib topical, tell your doctor if you have any signs of infection such as fever, chills, shortness of breath, cough, body aches, tiredness, open sores or skin wounds, diarrhea, stomach pain, weight loss, painful urination, or coughing up blood.

Tell your doctor if you have or have ever had:

• an active or chronic infection;

• tuberculosis or have been near people who have tuberculosis;

• herpes zoster (also called shingles);

• hepatitis B or C;

• any type of cancer;

• if you recently received a vaccine or are scheduled to receive a vaccine;

• high cholesterol; or

• a heart attack, stroke, blood clot, or other heart problems.

Tell your doctor if you've had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.

Make sure you are current on all vaccines before you start using delgocitinib topical.

delgocitinib topical may increase your risk of certain types of skin cancer. Your healthcare provider will check your skin on a regular basis. Report any new or changing skin lesions.

It is not known if delgocitinib topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

If you breastfeed, avoid touching your nipple area right away after applying delgocitinib topical to your hands and wrists.

How should I use delgocitinib topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the lowest effective dose for your condition.

Do not take by mouth. Delgocitinib topical is for use only on the skin of the hands and wrists.

Wash and dry your hands or wrists before applying this medicine. Use a mild soap to clean the skin area to be treated.

Use only a small amount of medicine. Apply a thin layer twice a day to the affected areas and rub in gently.

If a caregiver applies delgocitinib topical for you, they should wash their hands after applying this medicine.

You may get infections more easily, even serious or fatal infections.

You will need frequent medical tests before and during treatment with delgocitinib topical.

Store at room temperature away from moisture and heat. Do not freeze.

Delgocitinib topical dosing information

Usual Adult Dose for Eczema:

Apply a thin layer topically twice a day to affected areas of the hands and wrists only.
-Do not use more than 30 grams per 2 weeks OR 60 grams per month.

Comments:
-Prior to cream application, the affected areas should be cleaned and dried.
-Limitations of use: Not recommended in combination with other Janus kinase (JAK) inhibitors or potent immunosuppressants.

Use: For the topical treatment of moderate to severe chronic hand eczema in patients who have had an inadequate response to, or for whom topical corticosteroids are not advisable

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.

What should I avoid while using delgocitinib topical?

Delgocitinib topical may increase your risk of of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid receiving a "live" vaccine right before starting, during, or right after treatment with delgocitinib topical. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Avoid getting delgocitinib topical in your eyes, nose, mouth, or genitals. If contact does occur, rinse well with water.

What other drugs will affect delgocitinib topical?

Tell your doctor about all your other medicines, especially:

• other JAK inhibitors such as baricitinib, tofacitinib, upadacitinib, ruxolitinib; or

• drugs that weaken the immune system.

This list is not complete. Other drugs may affect delgocitinib topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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