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Bempedoic acid

Generic Name: bempedoic acid (BEM pe DOE ik AS id)
Brand Name: Nexletol
Dosage Forms: oral tablet (180 mg)

Medically reviewed by Drugs.com on March 25, 2020. Written by Cerner Multum.

What is bempedoic acid?

Bempedoic acid is used together with diet and other medicines to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL).

Bempedoic acid is for use in adults with an inherited form of high cholesterol.

Bempedoic acid is also used to lower LDL cholesterol in adults with coronary artery disease (clogged arteries).

It is not known if bempedoic acid can lower the risk of complications related to high cholesterol (such as heart problems, heart attack, stroke, or death).

Bempedoic acid may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Bempedoic acid may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the arm, shoulder, or Achilles' tendon of the heel. This can happen within days or months after you start taking bempedoic acid. Tendon problems may be more likely in certain people (older adults, people with kidney disease, or people who take steroid medicine or certain antibiotics.

Tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);

  • liver disease;

  • gout; or

  • problems with your tendons.

Bempedoic acid may harm an unborn baby. Tell your doctor right away if you become pregnant.

You should not breastfeed while using bempedoic acid.

How should I take bempedoic acid?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take bempedoic acid with or without food.

You may need frequent medical tests.

Store at room temperature away from moisture and heat.

Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking bempedoic acid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Bempedoic acid side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking bempedoic acid and seek medical attention right away if you have signs of tendon rupture:

  • sudden pain, swelling, bruising, or tenderness;

  • stiffness, movement problems; or

  • or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).

Call your doctor at once if you have:

  • severe foot or toe pain;

  • joint pain or swelling;

  • warmth or redness over your joints; or

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Bempedoic acid dosing information

Usual Adult Dose for Heterozygous Familial Hypercholesterolemia:

180 mg orally once a day

Comments:
-This drug should be given with maximally tolerated statin therapy.
-Lipid levels should be checked within 8 to 12 weeks of treatment initiation.

Uses: As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in those requiring additional LDL-C lowering.

Usual Adult Dose for Cardiovascular Risk Reduction:

180 mg orally once a day

Comments:
-This drug should be given with maximally tolerated statin therapy.
-Lipid levels should be checked within 8 to 12 weeks of treatment initiation.

Uses: As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in those requiring additional LDL-C lowering.

What other drugs will affect bempedoic acid?

Tell your doctor about all other cholesterol medicines you use, especially:

This list is not complete. Other drugs may affect bempedoic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Bempedoic acid interact with my other drugs?

Enter other medications to view a detailed report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.