Amlodipine and valsartan
Generic Name: amlodipine and valsartan (am LOE de peen val SAR tan)
Brand Name: Exforge
Medically reviewed: July 18, 2017
What is amlodipine and valsartan?
Amlodipine is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.
Valsartan is an angiotensin II receptor antagonist. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
Amlodipine and valsartan is usually given after other blood pressure medicines have been tried without success.
Amlodipine and valsartan may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
Before taking this medicine
If you have diabetes, do not use amlodipine and valsartan together with any medication that contains aliskiren (such as Tekturna or Tekamlo).
You may also need to avoid taking amlodipine and valsartan with aliskiren if you have kidney disease.
To make sure amlodipine and valsartan is safe for you, tell your doctor if you have ever had:
a heart attack;
liver disease; or
if you are on a low-salt diet.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Amlodipine and valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
It is not known whether amlodipine and valsartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Amlodipine and valsartan is not approved for use by anyone younger than 18 years old.
How should I take amlodipine and valsartan?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take this medication with or without food.
Your blood pressure will need to be checked often. Your kidney function may also need to be checked.
If you need surgery, tell the surgeon ahead of time that you are using amlodipine and valsartan.
It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Blood pressure medication is only part of a complete treatment program that may also include diet, exercise, regular blood pressure checks, lifestyle changes, and other medications. Follow your doctor's instructions very carefully.
Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or stop taking any of your medications without your doctor's advice.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking amlodipine and valsartan?
Do not use potassium supplements or salt substitutes while you are taking amlodipine and valsartan, unless your doctor has told you to.
Drinking alcohol can further lower your blood pressure and may cause side effects.
Amlodipine and valsartan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Amlodipine and valsartan side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
swelling in your hands or feet, rapid weight gain; or
signs of an electrolyte imbalance--dry mouth, increased thirst, drowsiness, confusion, feeling restless, vomiting, muscle pain or weakness, lack of energy, fast heartbeats, little or no urine, or a seizure.
Common side effects include:
swelling in your hands or feet;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Amlodipine and valsartan dosing information
Usual Adult Dose for Hypertension:
Initial therapy: Amlodipine 5 mg-Valsartan 160 mg orally once a day
Add-on/Replacement therapy: Amlodipine 5 to 10 mg-Valsartan 160 to 320 mg orally once a day
-May increase dose after 1 to 2 weeks of therapy.
-A patient who experiences dose-limiting adverse reactions on either component alone may be switched to this drug containing a lower dose of that component in combination with the other. If blood pressure remains uncontrolled after 3 to 4 weeks, may titrate up to a maximum of amlodipine 10 mg-valsartan 320 mg orally once a day.
What other drugs will affect amlodipine and valsartan?
Many drugs can interact with amlodipine and valsartan. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
all your heart or blood pressure medicines;
a diuretic or "water pill";
vitamin or mineral supplements that contain potassium;
simvastatin or other cholesterol medication;
This list is not complete and many other drugs can interact with amlodipine and valsartan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about amlodipine/valsartan
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- Drug class: angiotensin II inhibitors with calcium channel blockers
Other brands: Exforge