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What is the mechanism of action for Caplyta?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 25, 2025.

Official Answer by Drugs.com

Caplyta (lumateperone) affects neurotransmitter activity in the brain, helping to regulate dopamine, serotonin, and glutamate—chemicals linked to mood and schizophrenia symptoms.

Is Caplyta a Mood Stabilizer or an Antipsychotic?

Caplyta is classified as an atypical antipsychotic. It is used to treat:

Related questions

Should Caplyta Be Taken with Food?

Caplyta can be taken with or without food. The standard dosage is 42 mg once daily. If you have moderate to severe liver impairment, your doctor may adjust the dose to 21 mg once daily.

What Are the Common Side Effects of Caplyta?

In clinical studies, common side effects included:

This is not all the information you need to know about Caplyta (lumateperone) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

Brisch, R., et. al. (2014). The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue. In: Frontiers in Psychiatry. Accessed 05/31/2024 at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032934/


Caplyta [package insert]. (2023). Intra-Cellular Therapies, Inc. Accessed 05/31/2024 at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=db730b06-6351-47fd-8183-e61e61bbead5

Cooper, D., et. al. (2023). Lumateperone. In: StatPearls [Internet]. Accessed 05/31/2024 at: https://www.ncbi.nlm.nih.gov/books/NBK560844/

Edinoff, A., et. al. (2020). Lumateperone for the Treatment of Schizophrenia. In: Psychopharmacology Bulletin. Accessed 05/31/24 at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511146/

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