How is Tzield administered?
Tzield is given by intravenous infusion over a minimum of 30 minutes once daily for 14 consecutive days. Dosage is based on body surface area and increases as follows:
- Day 1: 65 mcg/m2
- Day 2: 125 mcg/m2
- Day 3: 250 mcg/m2
- Day 4: 500 mcg/m2
- Days 5 through 14: 1,030 mcg/m2.
Tzield needs to be diluted before administration and patients should be premedicated with an NSAID or acetaminophen, an antihistamine, and/or an antiemetic, approximately one hour before administration of the infusion for at least the first 5 days of the infusion.
Only one dose should be administered per day. If a dose is missed, just resume the remaining doses on consecutive days to complete the 14-day treatment course.
References
- Tzield Injection Prescribing Information. Updated 11/2022. Provention Bio, Inc. https://www.drugs.com/pro/tzield-injection.html
- FDA Approves First Drug That Can Delay Onset of Type 1 Diabetes. November 17, 2022. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-can-delay-onset-type-1-diabetes
Read next
What is Tzeild?
Tzield (teplizumab-mzwv) is an injectable medicine that is used to delay the onset of stage 3 Type 1 diabetes in people whose immune system has begun attacking their insulin-producing cells. Continue reading
How does Tzield work?
Tzield is thought to work by binding to CD3 (a cell surface antigen present on T lymphocytes) to delay the onset of stage 3 type 1 diabetes in adults and children 8 and older with stage 2 type 1 diabetes. Tzield may also deactivate the immune cells that attack insulin-producing cells while increasing the proportion of cells that help moderate the immune response. Tzield is classified as an anti-CD3 monoclonal antibody. Continue reading
How effective is Tzield?
Tzield has been shown to delay the progression of Stage 2 type 1 diabetes to Stage 3 type 1 diabetes by 25 months (approximately 2 years) in a phase 3, randomized, double-blind clinical trial. In an extended follow-up of this trial (duration 923 days), the average time to diagnosis of stage 3 type 1 diabetes was 59.6 months for Tzield-treated patients compared with 27.1 months for patients given a placebo (a difference of 32.5 months). Continue reading
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