How does Tzield work?
Tzield is thought to work by binding to CD3 (a cell surface antigen present on T lymphocytes) to delay the onset of stage 3 type 1 diabetes in adults and children 8 and older with stage 2 type 1 diabetes.
Tzield may also deactivate the immune cells that attack insulin-producing cells while increasing the proportion of cells that help moderate the immune response. Tzield is classified as an anti-CD3 monoclonal antibody.
References
- Tzield Injection Prescribing Information. Updated 11/2022. Provention Bio, Inc. https://www.drugs.com/pro/tzield-injection.html
- Sims, E. K., Bundy, B. N., Stier, K., Serti, E., Lim, N., Long, S. A., Geyer, S. M., Moran, A., Greenbaum, C. J., Evans-Molina, C., Herold, K. C., & Type 1 Diabetes TrialNet Study Group (2021). Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. Science translational medicine, 13(583), eabc8980. https://doi.org/10.1126/scitranslmed.abc8980
Read next
What is Tzeild?
Tzield (teplizumab-mzwv) is an injectable medicine that is used to delay the onset of stage 3 Type 1 diabetes in people whose immune system has begun attacking their insulin-producing cells. Continue reading
How effective is Tzield?
Tzield has been shown to delay the progression of Stage 2 type 1 diabetes to Stage 3 type 1 diabetes by 25 months (approximately 2 years) in a phase 3, randomized, double-blind clinical trial. In an extended follow-up of this trial (duration 923 days), the average time to diagnosis of stage 3 type 1 diabetes was 59.6 months for Tzield-treated patients compared with 27.1 months for patients given a placebo (a difference of 32.5 months). Continue reading
How is Tzield administered?
Tzield is given by intravenous infusion over a minimum of 30 minutes once daily for 14 consecutive days. Dosage is based on body surface area and increases. Continue reading
See also:
Aimovig
Learn about Aimovig (erenumab-aooe) a once-monthly, injectable medication that can be ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Topamax
Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine ...
Emgality
Emgality (galcanezumab-gnlm) is a CGRP antagonist for the preventive treatment of migraine and for ...
Timolol
Timolol is used for angina, heart attack, high blood pressure, migraine, migraine prevention
Valproic acid
Valproic acid is used for bipolar disorder, cluster-tic syndrome, epilepsy, headache ...
Divalproex sodium
Divalproex sodium is used for bipolar disorder, borderline personality disorder, cyclothymic ...
Propranolol
Propranolol is a beta-blocker that is used to treat tremors, chest pain, high blood pressure, heart ...
Related medical questions
- What foods should I eat or avoid for hypoglycemia?
- Always Hungry? You Might Have One Of These 12 Conditions
- Can you have hypoglycemia without diabetes?
- Which type of insulin has the longest duration of action?
- A1C levels: Dangerous vs normal and how to lower It?
- Basaglar and Lantus - What is the difference between them?
- When should I take Lantus?
- Levemir vs Lantus: What's the difference?
- Does Lantus insulin need to be refrigerated?
- Toujeo vs Lantus - What's the difference between them?
- What is the difference between regular insulin and lispro (Humalog)?
- Humalog vs Novolog (Novalog): What's the difference?
- How long does Lantus last?
- Are Humulin and Humalog the same thing?
- How to test for hypoglycemia at home?
- Toujeo vs Tresiba - What's the difference between them?
- Are glucagon and glycogen the same thing?
- Is Tresiba the same as Lantus?
- How do beta-blockers mask hypoglycemia?
- Humulin N vs Humulin R - What's the difference?
- Is Novolin the same as Humulin?
- When is the best time to take Toujeo?
- How do you use the Lantus pen (Lantus SoloStar)?
- How long can Toujeo stay out of the refrigerator?
- How long can Tresiba be out of the fridge?
- What are the different types of insulin?
- When does insulin lispro peak / how long does it last?
- How much Toujeo is too much?
- Can you take Tresiba twice a day?
- Soliqua vs Lantus: What’s the difference between them?
Drug information
Related support groups
- Teplizumab (4 questions, 3 members)
- Tzield (4 questions, 3 members)
- Diabetes, Type 1 (83 questions, 143 members)