What type of drug is Pifeltro (doravirine)?
Pifeltro (doravirine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used for the treatment of HIV-1 infection.
Non-nucleoside reverse transcriptase inhibitors are antiviral agents that bind non-competitively to HIV-1 reverse transcriptase and prevent viral RNA conversion to DNA. These drugs work by preventing HIV from multiplying in the body. NNRTIs are used in combination with other antiretroviral medicines.
Pifeltro is indicated for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg:
- with no prior antiretroviral treatment history, OR
- to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine.
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Can Descovy be used for PrEP in HIV?
Yes. The FDA approved Descovy (emtricitabine and tenofovir alafenamide) for pre-exposure prophylaxis (PrEP) in October 2019 to help reduce the risk of HIV-1 infection. Continue reading
Modafinil (Provigil) vs Adderall: What's the difference?
Modafinil and Adderall are both classified as CNS stimulants but have different chemical structures, which means there are differences in their addiction potential and risk of side effects. Modafinil and Adderall both have stimulant-type effects, but modafinil is a much milder stimulant than Adderall.
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Which medicines should not be taken with Biktarvy?
- Biktarvy is a complete regimen and use with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.
- Biktarvy is associated with many drug interactions as it contains three different medicines, increasing your risk for interactions. Have your health care provider check for possible interactions with other prescription medicines, OTCs or herbal you take.
- You should not take Biktarvy with dofetilide (Tikosyn), a drug used for heart rhythm disorders or rifampin (Rifadin), a medicine for tuberculosis (TB). These drugs are contraindicated with the use of Biktarvy.
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Drug information
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