What type of drug is Pifeltro (doravirine)?

Pifeltro (doravirine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used for the treatment of HIV-1 infection in adults.

Non-nucleoside reverse transcriptase inhibitors are antiviral agents that bind non-competitively to HIV-1 reverse transcriptase and prevent viral RNA conversion to DNA. These drugs work by preventing HIV from multiplying in the body. NNRTIs are used in combination with other antiretroviral medicines.

Pifeltro is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adult patients:

• with no prior antiretroviral treatment history, OR
• to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine.