Generic Name: doravirine (DOR a VIR een)
Brand Names: Pifeltro
Medically reviewed on Oct 17, 2018
What is Pifeltro?
Pifeltro is used together with other medicines to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).
Pifeltro is not a cure for HIV or AIDS.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with Pifeltro, and some drugs should not be used together.
Pifeltro side effects
Get emergency medical help if you have signs of an allergic reaction to Pifeltro: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Doravirine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common Pifeltro side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking this medicine
You should not use Pifeltro if you are allergic to doravirine.
Some medicines can cause unwanted or dangerous effects when used with Pifeltro. Your doctor may change your treatment plan if you have used any of the following medicines in the past 4 weeks:
St. John's wort; or
Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
This medicine is not approved for use by anyone younger than 18 years old.
How should I take Pifeltro?
Take Pifeltro exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Take Pifeltro at the same time each day, with or without food.
Pifeltro is usually taken once per day. If you also take a medicine called rifabutin, you may need to take doravirine twice per day. Follow your doctor's dosing instructions very carefully.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.
Store tablets at room temperature, away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
Do not put the tablets into a daily pill box.
Pifeltro dosing information
Usual Adult Dose for HIV Infection:
100 mg orally once a day
Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in patients with no prior antiretroviral treatment history
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely. Skipping doses may increase the risk of your virus becoming resistant to medication.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Pifeltro?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What other drugs will affect Pifeltro?
Tell your doctor about all your other medicines, especially:
rifabutin (or if you have taken it in the past 4 weeks).
This list is not complete. Other drugs may interact with doravirine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Pifeltro only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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