Can Stribild be crushed?
Yes, Stribild tablets can be crushed or cut to ease administration to people who have difficulty swallowing the tablets. The effects of crushing Stribild and then combining the crushed tablet with liquid nutrition were investigated in 24 volunteers. There was no difference in most pharmacokinetic parameters, such as the area under the curve between the people receiving crushed Stribild and those receiving a whole tablet with breakfast. A difference in the maximum concentration of Stribild was noted between the two groups, but this was considered not clinically relevant. People with swallowing difficulties or needing liquid feeding can safely use crushed and suspended Stribild tablets.
Stribild is a four-dose fixed combination of elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (tdf) that is a complete regimen for the treatment of HIV-1 infection in adults and pediatric patients 12 years of age and older weighing at least 35kg with no prior HIV treatment history.
References
Jongbloed-de Hoon M, Colbers A, Velthoven-Graafland K, Duisenberg-van Essenberg M, Kruijssen M, Abbink E, van Crevel R, Burger D. Brief Report: Pharmacokinetics of Crushed Elvitegravir Combination Tablet Given With or Without Enteral Nutrition. J Acquir Immune Defic Syndr. 2017 Apr 15;74(5):571-574. doi: 10.1097/QAI.0000000000001296. PMID: 28166190.
Read next
Is Stribild used for PrEP?
What medicines should not be taken with Stribild?
Stribild interacts with a large number of medications, including antacids, anticonvulsants, antidepressants, antifungals, antipsychotics, benzodiazepines, colchicine, corticosteroids, direct oral anticoagulants, ergot derivatives, heart medications, hormonal contraceptives, immunosuppressants, lipid-modifying agents, narcotic analgesics, PDE-5 inhibitors, salmeterol, and other antivirals. Continue reading
Does Stribild cause weight gain?
Weight gain is not listed as a side effect in the product information for Stribild, but a large study suggests that some of the newer HIV treatments, including those containing integrase strand inhibitors such as elvitegravir (found in Stribild), can be linked with significant weight gain. Over 96 weeks, elvitegravir was associated with a mean weight gain of 2.72 kg [6 lbs] (95% CI, 2.45–3 kg). Continue reading
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Drug information
- Stribild Information for Consumers
- Stribild prescribing info & package insert (for Health Professionals)
- Side Effects of Stribild (detailed)
- Stribild user reviews (88)
Related support groups
- Stribild (8 questions, 22 members)
- HIV Infection (99 questions, 250 members)