How is the new Primatene Mist different to the old formulation?
Medically reviewed by Drugs.com. Last updated on Nov 21, 2024.
Why was the old Primatene Mist removed from the market?
The new Primatene Mist is a metered dose inhaler (MDI) of epinephrine containing hydrofluoroalkane (HFA) propellants instead of CFC propellants.
In 2011, OTC Primatene Mist (epinephrine) was removed from U.S. pharmacy shelves due to international agreements to phase out products worldwide containing ozone-depleting chlorofluorocarbons (CFCs). However, in 2018 Primatene Mist returned to the U.S. market with a newly patented formulation.
- Primatene Mist is used for the temporary relief of mild symptoms of intermittent asthma (eg, wheezing, chest tightness, shortness of breath) in patients aged ≥12 years.
- The new mixture of Primatene Mist is a metered dose inhaler (MDI) of epinephrine containing hydrofluoroalkane (HFA) propellants instead of CFC propellants.
- The product’s new inhalation delivery system also provides a built-in spray indicator and a metal canister which replaces the original glass container.
- Primatene Mist returns as the only FDA-approved asthma inhaler available without a prescription in the U.S.
- View the step-by-step directions for use below.
If you have used Primatene Mist for asthma symptoms, see a doctor if:
- you are not better in 20 minutes or get worse
- need more than 8 inhalations in 24 hours
- have more than 2 asthma attacks in a week.
These may be signs that your asthma is getting worse. Asthma can be a life threatening condition if not properly treated.
Read next
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If someone is having an anaphylactic reaction, and all you have on hand is a recently expired EpiPen, then use it so long as it is not discolored and does not contain any particles. There is minimal risk in using a recently expired EpiPen, but the benefits are significant. But check the clear viewing window of the pen and if you notice it is discolored or contains particles then don’t use it as the solution may have oxidized, making it less effective. Continue reading
Can you bring an EpiPen on a plane?
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What's the mechanism of action for epinephrine?
Epinephrine works by activating both alpha and beta receptors found in your body in response to a severe allergy (called anaphylaxis). By acting on alpha receptors, it helps to maintain your blood pressure and heart function, and by acting on beta receptors, it relaxes your lung airways to help relieve shortness of breath and wheezing. Continue reading
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Drug information
- Primatene Mist Information for Consumers
- Primatene Mist prescribing info & package insert (for Health Professionals)
- Side Effects of Primatene Mist (detailed)
- Primatene Mist user reviews (43)
Related support groups
- Primatene Mist (3 questions, 15 members)
- Asthma (126 questions, 473 members)