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How long does it take for Lyrica to work?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on May 15, 2024.

Official answer

by Drugs.com

Key Points

  • In clinical studies with Lyrica (pregabalin) some patients experienced a decrease in pain as early as the first week, which persisted during the entire study period.
  • These studies looked at fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles. The length of the studies ranged from 5 weeks to 13 weeks long.
  • Your results may vary. Lyrica begins working right away but for some people it may take several weeks to feel the pain-relieving effects from Lyrica.

If you are not feeling the pain relief you expect, contact your doctor, who may need to adjust your dose or reassess your pain level.

Related questions

Can you take Lyrica long-term?

You should take Lyrica every day as prescribed by your doctor. Many people will take Lyrica long-term to help control their pain or seizures.

Don’t stop taking Lyrica without talking to your doctor first. If you need to stop taking Lyrica, your doctor will slowly discontinue it over a period of time, usually at least one week.

Abruptly stopping Lyrica may lead to side effects such as headaches, diarrhea, nausea, anxiety, problems with sleep, and increased sweating. If you take Lyrica for epilepsy and suddenly stop your medicine, your seizures may occur more often.

This is not all the information you need to know about Lyrica for safe and effective use. Review the full Lyrica (pregabalin) information here, and discuss this information and any questions with your doctor or other health care provider.

References

Read next

Is Lyrica a controlled substance / narcotic?

Lyrica (pregabalin) is a Schedule V (Schedule 5) controlled substance, the lowest schedule for abuse potential, as defined by the DEA. It is not a narcotic (opioid), but is used to treat various types of nerve pain (diabetic neuropathy, herpes zoster), as well as epilepsy, fibromyalgia and spinal cord injury. Continue reading

Does Lyrica make you sleepy?

Yes, Lyrica (pregabalin) can cause extreme drowsiness (somnolence) and may affect your ability to drive, operate machinery, or do other dangerous activities. This may lead to an injury or fall. In studies, up to 20% of children and 35% of adults experienced drowsiness as a side effect. Continue reading

Does Lyrica cause weight gain?

Weight gain is a common side effect associated with Lyrica treatment. In studies, 9% of Lyrica-treated patients and 2% of placebo-treated patients gained 7% or more compared to their weight at the beginning of the study. Lyrica is also linked with an increase in appetite and fluid retention. Continue reading

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