How long can Dupixent stay out of the fridge?
Dupixent can stay out of the fridge for a maximum of 14 days at room temperature (up to 77°F [25°C]). If you do not use it within 14 days, then it must be thrown away. Do not expose Dupixent to temperatures above 77°F (25°C) and do not put it back in the refrigerator if it has been inadvertently left out and allowed to warm up to room temperature.
Keep your stock of Dupixent refrigerated at between 2°C to 8°C [36°F to 46°F]) until you want to use it. Store in the original carton to protect from light. Do not shake, heat, freeze, or put the pens in direct sunlight
References
- Dupixent Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/761055s064lbl.pdf
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Why do Dupixent injections hurt so much?
Dupixent (dupilumab) injections can cause discomfort for some people. The amount of discomfort can depend on many factors.
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How fast does Dupixent work?
Dupixent (generic name: dupilumab) can start to work in 2 to 4 weeks to relieve symptoms associated with inflammatory conditions like eczema, asthma, and sinus swelling due to nasal polyps. In studies, improvements were seen at 12 weeks in some patients with chronic obstructive pulmonary disease (COPD), prurigo nodularis and chronic spontaneous urticaria; at 16 weeks with bullous pemphigoid; and at 24 weeks for eosinophilic esophagitis.
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Why does Dupixent cause eye problems?
Dupixent is associated with several different eye problems, including conjunctivitis, blepharitis, dry eyes, itchy eyes, and keratitis. The cause of the eye problems is thought to be due to Dupixent blocking interleukin-13 (IL-13), an inflammatory protein that also stimulates the production of goblet cells. Goblet cells are responsible for creating mucus in the eye and ensuring the stability of tears. So when Dupixent blocks IL-13 it also lowers the numbers of epithelial goblet cells leading to eye inflammation and eye problems. Continue reading
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