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How Fast Does Benadryl Work? Onset Time and Duration

Medically reviewed by Carmen Pope, BPharm. Last updated on July 22, 2025.

Official Answer by Drugs.com

Benadryl starts working within 30 minutes after taking it orally, with peak effects reached in 1-2 hours. The antihistamine effects last 4-6 hours for most people. Injectable Benadryl works even faster than oral tablets, providing quicker relief for severe allergic reactions.

You'll know Benadryl is working when your specific allergy symptoms start improving within the first hour of taking it.

How Will I Know Benadryl is Working?

Allergy symptom relief typically begins within 30 minutes:

Benadryl Timing overview

References

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