Is Leqvio FDA approved as a high cholesterol treatment?
Yes, Leqvio is FDA approved as a high-cholesterol treatment and it specifically lowers LDL cholesterol levels (sometimes referred to as "bad" cholesterol).
Leqvio is used with diet and exercise to reduce LDL cholesterol in adults with high cholesterol, including those with familial hypercholesterolemia.
Leqvio is an injection given subcutaneously (under the skin) by a healthcare provider 2 times a year.
References
- Leqvio Prescribing Information. https://www.novartis.com/us-en/sites/novartis_us/files/leqvio.pdf
- Lamb Y. N. (2021). Inclisiran: First Approval. Drugs, 81(3), 389–395. https://doi.org/10.1007/s40265-021-01473-6
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What is the difference between Leqvio and Repatha?
Leqvio and Repatha are both injectable medicines that are used for the treatment of high cholesterol, by specifically lowering low density lipoprotein (LDL) levels. Although they both inhibit PCSK9 they work by different mechanisms. Repatha is a monoclonal antibody that binds directly to PCSK9 in the liver preventing it from binding to LDL receptors. Leqvio blocks the PCSK9 protein by interfering with the translation of PCSK9 messenger RNA. Both have the same result – and that is freeing up LDL receptors on the surface of liver cells which allows LDL cholesterol to be removed from the blood.
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What are PCSK9 Inhibitors and how do they work?
The PCSK9 inhibitors are used for the treatment of patients with elevated cholesterol, especially when statins aren't adequate. They work by blocking PCSK9, leaving more receptors available to capture your "bad" cholesterol (LDL) for break down and removal from the blood.
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Can Leqvio be taken without a statin?
Yes, Leqvio can be prescribed without a statin and is FDA-approved for first-line use without a statin.
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Drug information
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