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Does Kerendia lower blood pressure?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on July 15, 2025.

Official Answer by Drugs.com

Yes, low blood pressure (hypotension) has been reported as a common side effect with oral Kerendia tablets, occurring in at least 1% (1 out of every 100) of patients. In studies, low blood pressure (hypotension) occurred in 4.6% of patients taking Kerendia compared to 3% of patients taking a placebo.

In patients treated with Kerendia, the mean systolic blood pressure (the first or top number) decreased by 3 mmHg and the mean diastolic blood pressure (the second or bottom number) decreased by 1-2 mmHg during the first month, but remained stable thereafter. A normal blood pressure reading is usually less than 120 / 80 mmHg.

Kerendia can also cause high potassium levels and low sodium levels.

Before starting treatment and while you are taking Kerendia, your doctor will monitor your potassium levels and kidney function using a simple blood test from your vein.

If you have any side effects, contact your doctor immediately to discuss them. Your doctor may need to change your dose. Do not change doses or stop the medication on your own. Call your healthcare provider for medical advice about side effects.

When was Kerendia approved by the FDA?

The FDA first approved Bayer’s Kerendia (finerenone) tablets in July 2021. It is classified as a non-steroidal, selective mineralocorticoid receptor antagonist (MRA) for the treatment of adults with:

Kerendia is approved to reduce the risk of:

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How it works

Kerendia belongs to a class of medicines called mineralocorticoid receptor (MR) antagonists.

The mechanism of how Kerendia works is thought to be due to blocking of the overactive mineralocorticoid receptor (on the kidney, heart or blood vessels) that may contribute to fibrosis (tissue scarring), inflammation and permanent damage in patients with type 2 diabetes or heart failure.

Kerendia blocks the mineralocorticoid receptor to lower activity and reduce inflammation and damage to the kidneys, blood vessels, and heart. Kerendia can slow chronic kidney disease from getting worse and also lower the risk of heart-related death, like having a heart attack, or needing to be hospitalized or have urgent visits for heart failure.

Phase 3 Studies for Kerendia

In Phase 3 studies for CKD, 5,674 patients received either Kerendia (2833) or placebo (2841) and were followed for 2.6 years. Kerendia use in adults lowered the risk of:

In Phase 3 studies of patients with heart failure with left ventricular ejection fraction (LVEF) ≥ 40%, results showed that Kerendia achieved:

This is not all the information you need to know about Kerendia (finerenone) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

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