What's the dosing schedule for Skyrizi?
After your initial starter doses, you'll receive Skyrizi as a subcutaneous (under the skin) maintenance dose every 12 weeks (4 times per year) to treat either plaque psoriasis or psoriatic arthritis, or every 8 weeks (6 times per year) for Crohn's disease or ulcerative colitis.
You can self-administer maintenance injections into your thigh or stomach area at home after proper training from your healthcare provider. Your healthcare provider will tell you your exact dose to use.
Plaque psoriasis and psoriatic arthritis
For the treatment of plaque psoriasis and psoriatic arthritis in adults, you’ll receive your first two starter subcutaneous (injected under the skin) doses of Skyrizi 4 weeks apart, then you’ll have an injection every 12 weeks thereafter. It is given from a prefilled pen or prefilled syringe.
- If you are being treated for psoriatic arthritis, your may receive Skyrizi alone or in combination with non-biologic disease-modifying antirheumatic drugs (DMARDs), such as methotrexate.
- Once you start your Skyrizi maintenance injections, you’ll have only 4 doses per year.
- You may self-administer these injections after proper training from your healthcare provider.
Crohn's disease
For treatment of Crohn's disease in adults, the dosing schedule is 3 intravenous (given into a vein) starter doses given 4 weeks apart (at Week 0, 4 and 8), then a subcutaneous (under the skin) injection given at Week 12, followed by a subcutaneous injection every 8 weeks thereafter.
- After completing the initial starter doses, you may receive Skyrizi as an injection under the skin (subcutaneous) using the prefilled cartridge with an on-body injector (OBI) or by a prefilled syringe.
- You can administer this at home after training from your healthcare provider. The injection OBI dose is delivered in about 5 minutes and you will not see the needle.
Ulcerative colitis
For treatment of moderately to severely active ulcerative colitis in adults:
- The dosing schedule is 3 intravenous (given into a vein) starter doses given 4 weeks apart (at Week 0, 4 and 8), then a subcutaneous (under the skin) injection given at Week 12, followed by an injection every 8 weeks thereafter.
- Following the induction period, Skyrizi treatment can be maintained at home using an on-body injector (OBI) or by a prefilled syringe. The OBI injection dose is delivered in about 5 minutes and you will not see the needle.
Before use, you should receive training on how to inject the medicine. Be sure to read the instructions for use before you start using Skyrizi and each time you get a refill. There may be new information you need to know. If you do not have the instructions, ask your pharmacist for a copy. Use this medicine exactly as directed by your doctor.
Related questions
- What does psoriasis look like?
- How do you get psoriasis and is it contagious?
- How does Tremfya work?
Can I use Skyrizi at home?
Yes, for treatment of plaque psoriasis and psoriatic arthritis you can inject Skyrizi subcutaneously (under the skin) into your thigh or stomach area (abdomen) using a prefilled syringe or a pen injector, after training from your healthcare provider. You may also receive these injections at your doctor’s office if you prefer.
For Crohn's disease and ulcerative colitis, the initial starter doses are given intravenously (into a vein) in a clinic. Then you will receive Skyrizi as an injection under the skin (subcutaneously) using the prefilled cartridge with an on-body injector or as a prefilled syringe. You can administer subcutaneous doses at home after training from your healthcare provider.
What is the typical dose of Skyrizi?
The recommended starter and maintenance dose of Skyrizi (risankizumab) for both plaque psoriasis and psoriatic arthritis is 150 mg given as a subcutaneous (under the skin) injection.
The recommended starter doses of Skyrizi for treatment of Crohn's disease is 600 mg administered by intravenous infusion over at least one hour for the first three doses (Week 0, 4, and 8). Then, the recommended maintenance dosage is 180 mg or 360 mg given by subcutaneous (under the skin) injection at Week 12, and then every 8 weeks, thereafter.
The recommended starter doses of Skyrizi for treatment of ulcerative colitis is 1,200 mg administered by intravenous infusion over at least two hours for the first three doses (Week 0, 4, and 8). Then, the recommended maintenance dosage is 180 mg or 360 mg given by subcutaneous (under the skin) injection at Week 12, and then every 8 weeks, thereafter.
If a dose is missed, administer the dose as soon as possible, then resume dosing at the regularly scheduled time. If you inject too much Skyrizi, call your doctor right away for instructions.
Only use the dose of Skyrizi that your doctor prescribes.
This is not all the information you need to know about Skyrizi (risankizumab-rzaa) for safe and effective use and does not take the place of your healthcare provider's directions. Review the product information and discuss this information and any questions you have with your doctor or other health care provider.
References
- Skyrizi (risankizumab-rzaa) [prescribing information]. 6/2024. North Chicago, Ill. AbbVie Inc. Accessed June 19, 2024 at https://www.rxabbvie.com/pdf/skyrizi_pi.pdf
- Skyrizi dosing. AbbVie Inc. Accessed June 19, 2024 at https://www.skyrizi.com/psoriasis-psoriatic-arthritis/about-skyrizi/dosing-and-taking-skyrizi
Read next
How does Ilumya work to treat psoriasis?
Ilumya works by binding selectively to interleukin-23 (IL-23) which is a naturally occurring cytokine. IL-23 plays a key role in promoting inflammation and regulating other cytokines (such as IL-17) and inflammatory substances, such as TNF-α3-7. By blocking the effects of IL-23, Ilumya helps control the release of IL-17 and TNF-α, which reduces inflammation associated with psoriasis. It also decreases how many inflammatory cells are present within psoriatic lesions, helps prevent plaque formation, and resolves tissue damage. Continue reading
What's a good prednisone taper schedule?
The best prednisone taper will depend upon how long you have been taking the medicine, your dose, and why you are being treated. If you've been treated with a high dose of prednisone, or taken it for more than a few weeks, you will need to slowly stop your medicine, usually over a period of days, weeks or months. Your healthcare provider will determine your prednisone tapering schedule. Continue reading
Prednisone: What are 12 Things You Should Know?
Prednisone has been on the market for more than 70 years but is still one of the most commonly prescribed anti-inflammatory or immunosuppressive medications. Prednisone is used to treat dozens of different conditions such as skin disorders, breathing disorders, allergies, arthritis, and ulcerative colitis. But did you know it also has some pretty serious side effects as well?
Continue readingSee also:
Related medical questions
- Where should you not use triamcinolone acetonide cream?
- What are the new drugs for plaque psoriasis?
- Why should I take folic acid with methotrexate?
- Is triamcinolone acetonide an antifungal cream?
- How do you use clobetasol propionate on your scalp?
- Clobetasol vs. triamcinolone - how do they compare?
- Sotyktu vs Otezla: How do they compare?
- What is a substitute for fluocinonide cream?
- What are IL-23 Inhibitors and how do they work?
- How long does methotrexate stay in your system?
- Halobetasol vs. clobetasol - How do they compare?
- Does taking vitamin D help with psoriasis?
- Can clobetasol be used for toenail fungus?
- How long does it take for Skyrizi to work?
- What are 6 key Taltz side effects to watch out for?
- What causes Plaque Psoriasis?
- How does Taltz compare to Cosentyx for psoriatic arthritis?
- How long does clobetasol stay in your system?
- Does Feverfew interact with any drugs?
- Is fluocinonide an antifungal cream?
- How long does it take for Otezla to work?
- How long should you use fluocinonide for?
- How do you inject Humira?
- Cosentyx vs Humira: How do they compare?
Drug information
- Skyrizi Information for Consumers
- Skyrizi prescribing info & package insert (for Health Professionals)
- Side Effects of Skyrizi (detailed)
- Skyrizi user reviews (65)
Related support groups
- Psoriasis (110 questions, 310 members)
- Skyrizi (19 questions, 9 members)
- Ulcerative Colitis (79 questions, 188 members)
- Psoriatic Arthritis (94 questions, 282 members)
- Plaque Psoriasis (96 questions, 69 members)