What is the difference between Soliqua and Xultophy?
Both products combine a long-acting insulin with a GLP-1 agonist – Xultopy brings together Tresiba (insulin degludec) and Victoza (liraglutide), while Soliqua combines Lantus (insulin glargine) with Adlyxin (lixisenatide).
Soliqua 100/33 is Sanofi’s once-daily injection used alongside diet and exercise to improve blood sugar control in adults type 2 diabetes. Soliqua 100/33 is a combination of insulin glargine 100 Units/mL (Lantus), a long-acting insulin, and lixisenatide 33 mcg/mL (Adlyxin), a glucagon-like peptide-1 (GLP-1) agonist.
Xultophy 100/3.6 is Novo Nordisk’s once-daily injection of insulin degludec 100 Units/mL (Tresiba), and the GLP-1 agonist liraglutide 3.6 mg/mL (Victoza), also used to treat type 2 diabetes in conjunction with diet and exercise. Insulin degludec is a long-acting insulin and liraglutide is a glucagon-like peptide-1 (GLP-1) agonist.
These two medications, available as injection pens, were the first approved in a novel group of type 2 diabetes treatments that combine a long-acting insulin with a GLP-1 agonist. They are not approved for the treatment of type 1 diabetes. These drugs are often used after other diabetes medications have been tried without success.
Long-acting insulins start working several hours after injection and continue to work steadily for 24 hours. Glucagon-like peptide-1 (GLP-1) agonists are similar to a hormone that occurs naturally in the body and helps to control blood sugar, insulin levels, and digestion. GLP-1 agonists may help you to lose weight.
GLP-1 agonists approved in the U.S. include:
- albiglutide (Tanzeum)
- dulaglutide (Trulicity)
- exenatide extended-release (Bydureon BCise)
- exenatide (Byetta)
- liraglutide (Victoza)
- lixisenatide (Adlyxin)
- semaglutide (Ozempic)
- semaglutide (Rybelsus)
All agents are given by injection except for Rybelsus from Novo Nordisk, the first oral GLP-1 agonist, approved in September 2019.
This is not all the information you need to know about Xultophy or Soliqua for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full product information, and discuss this information and any questions you have with your doctor or other health care provider.
Related questions
- Basaglar and Lantus - What is the difference between them?
- Toujeo vs Lantus - What's the difference between them?
- Biosimilars vs Biologics: What are they and how do they compare?
References
- Soliqua 100/33 (insulin glargine and lixisenatide injection), for subcutaneous use. [product information]. Accessed March 18, 2021 at https://products.sanofi.us/Soliqua100-33/Soliqua100-33.pdf
- Xultophy 100/3.6 (insulin degludec and liraglutide injection), for subcutaneous use. [product information]. Accessed March 18, 2021 at https://www.novo-pi.com/xultophy10036.pdf
Read next
Soliqua vs Lantus: What’s the difference between them?
Soliqua is a combination of insulin glargine plus lixisenatide, and Lantus only contains insulin glargine. Both are once-daily injections that are given under the skin (subcutaneously), but Soliqua can only be used in adults with type 2 diabetes whereas Lantus may be used to treat both type 1 and type 2 diabetes in adults and children over the age of six years. Both are made by Sanofi-Aventis. Continue reading
Is Admelog the same as NovoLog?
No, Admelog (insulin lispro) is not the same as NovoLog (insulin aspart). These insulins have different chemical structures but they are both man-made, rapid-acting forms of insulin used to help lower mealtime blood sugar (glucose) levels in patients with diabetes. Continue reading
Which GLP-1 drug is best for weight loss?
The most effective GLP-1 drug for weight loss currently (as of mid-2025) is tirzepatide, marketed under the names Zepbound (for weight loss) and Mounjaro (for diabetes).
Continue readingSee also:
Related medical questions
- When should I take Lantus?
- Levemir vs Lantus: What's the difference?
- Does Lantus insulin need to be refrigerated?
- What biosimilars have been approved in the United States?
- How long does Lantus last?
- Is Tresiba the same as Lantus?
- Can you mix Humalog with Lantus?
- How do you use the Lantus pen (Lantus SoloStar)?
- Does Lantus insulin raise or lower your blood sugar?
- Does Lantus cause weight gain?
- Which type of insulin has the longest duration of action?
- How do medications help with diabetes?
- How and where do you inject liraglutide?
- Can liraglutide be used for weight loss?
- When is the best time of day to take Victoza?
- Is there a list of drugs that require cold storage?
- Will Victoza help with weight loss?
- How many doses are in a Victoza pen?
- Does Victoza need to be refrigerated?
- How and where do you use the Victoza pen?
- Can Victoza and Januvia be used together?
Related support groups
- Lantus (47 questions, 121 members)
- Victoza (54 questions, 303 members)
- Insulin Glargine (14 questions, 9 members)
- Tresiba (13 questions, 19 members)
- Insulin Degludec (11 questions, 4 members)
- Soliqua (9 questions, 7 members)
- Xultophy (4 questions, 5 members)
- Insulin Degludec/liraglutide (3 questions, 3 members)
- Lixisenatide (3 questions, 3 members)
- Adlyxin (2 questions, 3 members)
- Insulin Glargine/lixisenatide (2 questions, 3 members)