What is the difference between Renflexis and Remicade?
Renflexis (infliximab-abda) is a tumor necrosis factor (TNF) blocker that is biosimilar to Remicade (infliximab).
According to the FDA, a biosimilar is shown to have no clinically meaningful differences in terms of safety and effectiveness from the reference product -- in this case Remicade. Only minor differences in clinically inactive components are allowable in biosimilar products.
Learn more: What Are Biosimilars? Top Facts You May Not Know
Renflexis is given as an intravenous (IV) infusion similar to Remicade, and is used for the same conditions, specifically treatment of:
- Crohn's disease
- ulcerative colitis
- rheumatoid arthritis
- ankylosing spondylitis
- psoriatic arthritis
- plaque psoriasis.
The first biosimilar to Remicade, Pfizer’s Inflectra (infliximab-dyyb) was approved by the FDA in April, 2016.
For more information, see Comparing Remicade vs Renflexis.
Related questions
- What are the new drugs for rheumatoid arthritis (RA)?
- What are Monoclonal Antibodies and how do they work?
- Biosimilars vs Biologics: What are they and how do they compare?
Which is more affordable, Renflexis or Remicade?
- The cost for one Renflexis intravenous powder for injection is around $796 per 100 mg vial.
- The cost for one Remicade intravenous powder for injection is around $1,229 per 100 mg vial.
- More than one vial may be needed for a full dose. Prices can vary based on insurance, pharmacies and locations.
Dosing is based on your weight and clinical condition. See more information here:
This is not all the information you need to know about Remicade or Renflexis for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full product information, and discuss this information and any questions you have with your doctor or other health care provider.
References
- Renflexis (infliximab-abda). Product information. Accessed April 5, 2021 at https://www.merck.com/product/usa/pi_circulars/r/renflexis/renflexis_pi.pdf
- Remicade (infliximab). Product information. Accessed April 5, 2021 at https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/REMICADE-pi.pdf
- Price Guide. Drugs.com. Accessed April 5, 2021 at https://www.drugs.com/price-guide/
Read next
What is the difference between Inflectra and Remicade?
Inflectra (infliximab-dyyb) is a biosimilar to Remicade (infliximab). They belong to the same class of drugs called tumor necrosis factor (TNF) alfa inhibitors. Inflectra can be prescribed for the same uses as Remicade, including rheumatoid arthritis, Crohn’s disease, ankylosing spondylitis, ulcerative colitis, psoriatic arthritis, and plaque psoriasis. Continue reading
What medications are known to cause hair loss?
Medication-induced hair loss represents a significant concern for patients across multiple therapeutic categories. While chemotherapy drugs are most commonly associated with severe hair loss, many commonly prescribed medications-including antibiotics, psychiatric drugs, cardiovascular agents, and hormonal therapies-can also cause this distressing side effect.
Continue reading
What is the mechanism of action of infliximab?
Infliximab works by binding specifically to a protein called TNF-α (tumor necrosis factor-alpha), which is released by white blood cells as part of our body’s immune response to infection or foreign substances. Overproduction of TNF-α can cause inflammation which can damage tissues, bones, and cartilage, and also cell death. When infliximab binds to TNF-α, it blocks its effects, and this reduces inflammation. Increased levels of TNF-alfa have been found in conditions such as rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Continue reading
See also:
Related medical questions
- What are the new drugs for plaque psoriasis?
- What biosimilars have been approved in the United States?
- What causes Plaque Psoriasis?
- What is the difference between Ixifi and Remicade?
- Which is worse: Ulcerative colitis or Crohn's disease?
- How does Tremfya work?
- What is low dose naltrexone (LDN)?
- What are JAK inhibitors and how do they work?
- Rinvoq Copay Card: Do I qualify and how much can I save?
- What are IL-23 Inhibitors and how do they work?
- How much does Entyvio cost per month?
- What are 7 key Stelara side effects to watch out for?
- Is Entyvio an immunosuppressant or a biologic?
- My stool has changed color. What does it mean?
- How long does it take Entyvio to start working?
- How do Rinvoq and Dupixent compare?
- Why is my poop green? What does this mean?
- How does Omvoh compare to Entyvio?
- Which JAK inhibitors are approved in the U.S?
- How do you inject Humira?
- What is the MOA and half-life for Rinvoq?
- How long does Cimzia take to work?
- Is Omvoh the same as Skyrizi?
- Can I take antibiotics while on Entyvio?
- What is the difference between Amjevita and Humira?
- Who is the actress in the Stelara commercial?
- Does Entyvio cause weight gain?
- Who makes Skyrizi and where is it made?
- Skyrizi vs Humira for plaque psoriasis - How do they compare?
- How and where is the Cimzia injection given?
Drug information
Related support groups
- Remicade (23 questions, 186 members)
- Infliximab (9 questions, 15 members)
- Renflexis (6 questions, 4 members)
- Crohn's Disease (66 questions, 286 members)
- Psoriatic Arthritis (94 questions, 282 members)
- Rheumatoid Arthritis (337 questions, 1,333 members)
- Plaque Psoriasis (96 questions, 69 members)
- Ankylosing Spondylitis (61 questions, 212 members)