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What is the difference between Andexxa and Praxbind?

Medically reviewed by Last updated on June 9, 2020.

Official Answer


Andexxa and Praxbind are both used to treat life-threatening or uncontrolled bleeding specifically due to certain anticoagulation agents, however they have different modes of action.

Andexxa (coagulation factor Xa [recombinant], inactivated-zhzo) is a recombinant modified human Factor Xa (FXa) protein intravenous injection, and the first drug approved to be used for reversal of anticoagulation for serious bleeding in patients treated with the Factor Xa inhibitors rivaroxaban (Xarelto) or apixaban (Eliquis).

Praxbind is an intravenous humanized monoclonal antibody fragment (Fab) that binds to Pradaxa (dabigatran) to neutralize its effect and control bleeding. Praxbind binds to dabigatran and its metabolites more strongly than the binding affinity of dabigatran to thrombin, neutralizing the anticoagulant effect.

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