Skip to Content


Generic Name: lesinurad (le SIN ure ad)
Brand Name: Zurampic

Medically reviewed by Last updated on Sep 11, 2020.

What is Zurampic?

Zurampic (lesinurad) helps the kidneys remove uric acid from the body. Lesinurad is used together with other medicines that can cause the body to produce less uric acid.

Zurampic is used as part of a combination of medicines to treat high levels of uric acid in your blood, also called hyperuricemia. High levels of uric acid can lead to a condition called gout.

Zurampic should be used together with allopurinol (Zyloprim) or febuxostat (Uloric). It should not be used alone.

Important information

You should not use Zurampic if you have severe kidney problems, or if you are on dialysis or have received a kidney transplant.

Zurampic can cause kidney failure, especially if you take it without your other prescribed medications. Call your doctor right away if you urinate less than usual or not at all, or if you have swelling in your feet or ankles, or shortness of breath.

Before taking this medicine

You should not use Zurampic if you are allergic to lesinurad, or if:

  • you have severe kidney disease;

  • you are on dialysis;

  • you received a kidney transplant;

  • you have Lesch-Nyhan syndrome (a genetic condition that increases uric acid levels in the blood); or

  • you have tumor lysis syndrome (rapid breakdown of cancer cells).

To make sure Zurampic is safe for you, tell your doctor if you have:

  • kidney disease;

  • liver disease;

  • heart disease; or

  • a stomach disorder called gastroesophageal reflux disease (GERD).

It is not known whether Zurampic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Zurampic can make birth control pills less effective. Ask your doctor about using a non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Other forms of hormonal contraception (injections, implants, skin patches, vaginal rings, and certain intrauterine devices) may not be effective enough to prevent pregnancy during your treatment with Zurampic.

It is not known whether lesinurad passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Zurampic is not approved for use by anyone younger than 18 years old.

How should I take Zurampic?

Take Zurampic exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Zurampic should be given in combination with other uric acid medication and it should not be used alone. Lesinurad is more likely to cause kidney failure if you take this medicine without your other prescribed medication.

Zurampic works best if you take it with food and water. Take Zurampic in the morning with your other medicine to control uric acid.

Drink at least 2 liters (68 ounces) of liquids every day to keep your kidneys working properly.

Gout symptoms may get worse when you first start taking Zurampic. Even if you have a gout flare-up, keep using the medication as directed.

Call your doctor if your gout symptoms do not eventually improve.

You may need medical tests to check your kidney function before and during treatment with Zurampic.

Store at room temperature away from moisture, heat, and light.

Zurampic dosing information

Usual Adult Dose of Zurampic for Gout:

200 mg orally once a day
Maximum dose: 200 mg per day

-Coadminister with a xanthine oxidase inhibitor (e.g., allopurinol or febuxostat); if coadministered with allopurinol, total daily allopurinol doses should not be less than 300 mg (or less than 200 mg with CrCl less than 60 mL/min).
-If xanthine oxidase inhibitor is interrupted, this drug should also be interrupted.
-This drug should not be used to treat asymptomatic hyperuricemia.

Use: Add-on treatment for hyperuricemia associated with gout in patients with elevated serum uric acid despite treatment with a xanthine oxidase inhibitor

What happens if I miss a dose?

Skip the missed dose if morning has already passed. Do not take Zurampic later in the day. Wait until the next day to take your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Zurampic?

Avoid becoming dehydrated while taking this medicine. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. Dehydration could lead to kidney failure.

Zurampic side effects

Get emergency medical help if you have signs of an allergic reaction to Zurampic: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • gout flare-up symptoms - joint pain, stiffness, redness, or swelling (especially at night);

  • kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

  • heart problems - chest pain or pressure, pain spreading to your jaw or shoulder; or

  • signs of a blood clot - sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.

Common Zurampic side effects may include:

  • abnormal kidney function tests;

  • heartburn;

  • headache; or

  • flu-like symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zurampic?

Many drugs can interact with lesinurad. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • aspirin;

  • valproic acid;

  • an antibiotic or antifungal medicine;

  • cholesterol medication;

  • heart or blood pressure medication;

  • hormonal birth control (pills, patches, implants, or certain intrauterine devices); or

  • other gout medications.

This list is not complete and many other drugs can interact with lesinurad. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zurampic only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.