Zurampic Side Effects
Generic Name: lesinurad
Medically reviewed by Drugs.com. Last updated on Sep 18, 2020.
Note: This document contains side effect information about lesinurad. Some of the dosage forms listed on this page may not apply to the brand name Zurampic.
Common side effects of Zurampic include: increased serum creatinine. Other side effects include: acute kidney injury. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to lesinurad: oral tablets
Side effects include:
For Healthcare Professionals
Applies to lesinurad: oral tablet
When used at labeled doses in combination with a xanthine oxidase inhibitor (XOI), serum creatinine increases of 1.5 to less than 2 times or 2 times or greater from baseline occurred in 3.9% (n=20/511) and 1.8% (n=9/511) of patients, respectively. Increased serum creatinine levels resolved in most patients (up to 90%) without treatment interruption. Based on baseline renal function, serum creatinine increases occurred in 3%, 3.8%, and 6.9% of patients with normal (CrCl greater than 90 mL/min), mild (CrCl 60 to less than 90 mL/min), or moderate (CrCl greater than 30 to less than 60 mL/min) renal impairment.
Use at higher than approved doses with or without an XOI resulted in increased serum creatinine levels. Consistently, patients receiving 400 mg daily as monotherapy experienced a higher incidence of renal failure. Nephrolithiasis occurred more frequently in patients receiving 400 mg daily in combination with an XOI (2.5%) compared to labeled doses in combination with an XOI (0.6%).[Ref]
Common (1% to 10%): Increased serum creatinine, renal failure
Uncommon (0.1% to 1%): Nephrolithiasis[Ref]
Common (1% to 10%): Headache[Ref]
Common (1% to 10%): Influenza[Ref]
Frequency not reported: Cardiovascular death, non-fatal myocardial infarction, non-fatal stroke[Ref]
Incidence rate ratios for major adverse cardiac events compared to placebo were 1.36 (95% CI: 0.23, 9.25) in 200 mg and 2.71 (95% CI: 0.66, 16) in 400 mg.[Ref]
1. "Product Information. Zurampic (lesinurad)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Frequently asked questions
More about Zurampic (lesinurad)
- During Pregnancy
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- 2 Reviews
- Drug class: antihyperuricemic agents
- FDA Approval History
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Some side effects may not be reported. You may report them to the FDA.