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Generic name: coagulation factor Xakoe-AG-ue-LAY-tion-FAK-tor-Xa ]
Drug class: Anticoagulant reversal agents

Medically reviewed by on Aug 16, 2023. Written by Cerner Multum.

What is Andexxa?

Andexxa is a protein that reverses the effects of certain anticoagulant medications that are used to treat or prevent blood clots. Reversing anticoagulant medicine is necessary if you have uncontrolled or life-threatening bleeding as a result of how that medicine works.

Andexxa is used to treat uncontrolled bleeding in people who take the anticoagulants rivaroxaban (Xarelto) and apixaban (Eliquis).

Andexxa was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, healthy volunteers responded to Andexxa, but further studies are needed.

Andexxa may also be used for purposes not listed in this medication guide.

Andexxa side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Andexxa may cause serious side effects. Call your doctor at once if you have:

Reversing the effects of anticoagulant medication may increase your risk of a blood clot, heart attack, stroke, or death. Get emergency medical help if you have any of these symptoms after being treated with Andexxa, especially if you have not started taking anticoagulant medication again:

Common side effects of coagulation factor Xa may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Andexxa is used to reverse the effects of anticoagulant medication, which may increase your risk of a blood clot, heart attack, stroke, or death. Watch for symptoms such as chest pain, sudden numbness or weakness, problems with vision or speech, and swelling or redness in an arm or leg.

Before taking this medicine

You should not be treated with Andexxa if you have had an allergic reaction to clotting factor medicine.

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received this medicine.

In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

How is Andexxa given?

Andexxa is given as an infusion into a vein. A healthcare provider will give you this injection.

Andexxa must be given slowly, and the infusion can take at least 2 hours to complete.

Once your bleeding has been controlled, you may need to begin using anticoagulant medication again to prevent future blood clots. Follow your doctor's instructions very carefully.

What happens if I miss a dose?

Because you will receive Andexxa in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving Andexxa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Andexxa?

Other drugs may affect Andexxa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Andexxa injection is an antidote that can be used for patients being treated with rivaroxaban (Xarelto) or apixaban (Eliquis) when reversal of anticoagulation (blood thinning) is needed due to life-threatening or uncontrolled bleeding. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.