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Medications for Reversal of Anticoagulation

Reversal of anticoagulation medication is indicated for patients who are on anticoagulant therapy and have life threatening or uncontrolled bleeding, or they need an emergency procedure or surgery.

Anticoagulation medications are used to reduce the ability of the blood to clot which can prevent and reduce recurrent venous thromboembolism, protect against stroke and reduce the risk of recurrent ischemic events. This reduced ability to clot can cause a complication of increased risk of major life-threatening bleeding due to other medical conditions or uncontrolled bleeding if an emergency procedures or surgery is required.

A medication that has the ability to reverse the effect of an anticoagulant is useful to control any major bleeding complications. Anticoagulant reversal agents are specific for each type of anticoagulant, depending on the anticoagulants mode of action.

Drugs used to treat Reversal of Anticoagulation

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Andexxa Rate Add review
Rx N

Generic name: coagulation factor Xa systemic

Drug class: anticoagulant reversal agents

For consumers: dosage, side effects

For professionals: Prescribing Information

coagulation factor Xa Rate Add review
Rx N

Generic name: coagulation factor Xa systemic

Brand name:  Andexxa

Drug class: anticoagulant reversal agents

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Topics under Reversal of Anticoagulation

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.