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Lexette foam

Pronunciation: lex-et
Generic name: halobetasol propionate 0.05%
Brand name: Lexette
Dosage form: foam
Drug class: Topical steroids

Medically reviewed by Carmen Pope, BPharm. Last updated on Mar 26, 2024.

What is Lexette?

Lexette foam is a super high potency, Class I corticosteroid foam that is applied to the skin to reduce inflammation and itching caused by plaque psoriasis in adults aged 18 years and older. Lexette contains halobetasol propionate 0.05%.

The foam is applied as a thin layer to the affected areas of the skin for a maximum of 2 consecutive weeks. Lexette foam is flammable, and you should avoid heat, open flames, or smoking while using this product. The canister may explode if it gets too hot. Do not puncture or burn an empty canister.

Lexette foam was FDA approved on May 24, 2018.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Lexette foam is a highly potent, Class I corticosteroid that can be absorbed through the skin into the bloodstream and cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency, including Cushing’s syndrome, hyperglycemia, and glucosuria. Do not use for longer than 2 weeks and do not use more than 50 grams per week. Periodic monitoring for HPA suppression may be required.

Before taking this medicine

You should not use Lexette if you are allergic to it.

Lexette foam should not be applied to lesions that are exuding serum or to skin folds (where two areas of skin touch each other).

Tell your doctor if you have ever had:

Topical corticosteroids can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.

Children are more susceptible to systemic absorption of topical corticosteroids. Lexette foam is not approved for use by young adults and children under the age of 18.

It is not known whether Lexette foam will harm an unborn baby. Tell your doctor if you are pregnant. If you are instructed to use the foam, use a small amount for the shortest time possible.

It may not be safe to breastfeed while using this medicine. If you are instructed to Lexette foam, use a small amount for the shortest time possible. Do not apply to the breasts.

How do I use Lexette foam?

Use Lexette foam exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Do not take it by mouth. Topical medicine is for use only on the skin. Do not use on open wounds or sunburned, windburned, dry, or irritated skin. Rinse with water if it gets in your eyes or mouth.

Do not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.

Lexette foam is for short-term use only up to 2 weeks. Follow your doctor's dosing instructions very carefully. Do not use more than 50 grams per week.

Call your doctor if your symptoms do not improve after 2 weeks, or if they get worse. Stop using the product if your symptoms improve sooner.

What happens if I miss a dose?

Apply the product as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

High doses or long-term use of Lexette foam can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using Lexette foam?

What are the side effects of Lexette foam?

Get emergency medical help if you have signs of an allergic reaction to Lexette foam, such as hives; difficulty breathing; or swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common Lexette side effects may include:

Other side effects reported with topical corticosteroids include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lexette foam?

Lexette foam is unlikely to interact with other medications you may take. But you should not use it with other topical or oral corticosteroids, because they may have an additive effect.

Tell your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.


Store at room temperature 20°C – 25°C (68°F – 77°F). Do not freeze.

The contents of Lexette foam are under pressure. Do not puncture or incinerate. Do not expose to heat or store at temperatures above 49°C (120°F).

Keep out of reach of children.


Active: halobetasol propionate 0.05%.

Inactive: alcohol (specially denatured alcohol [SDA]), benzoic acid, cetostearyl alcohol, emulsifying wax, polyoxyl 20 cetostearyl ether, propylene glycol, and purified water.

Available in 50-gram aluminum canisters pressurized with a hydrocarbon propellant containing isobutane and propane.


Pharmasol Corporation for Mayne Pharma.

Popular FAQ

No, halobetasol propionate is not available as an over-the-counter (OTC) product. Topical halobetasol is a highly potent prescription medicine used on the skin that reduces inflammation in psoriasis, eczema, dermatitis and other corticosteroid-responsive conditions. Continue reading

Halobetasol and clobetasol are both classified as super high-potency or high-potency topical corticosteroid (“steroid”) creams used on the skin. They are both FDA-approved to treat plaque psoriasis and skin conditions that are responsive to topical corticosteroids, such as dermatitis and eczema (atopic dermatitis). They lessen skin redness and pain, itching, dryness and scaling. Continue reading

Which topical corticosteroid (“steroid”) product is best for you depends upon what skin condition you have, your symptoms and where it is located on your body. Other selection factors may include availability, cost and if the medicine is covered by your insurance. After examination, your doctor will be able to determine which topical steroid is best to treat your skin condition. Continue reading

Halobetasol should not be used on the scalp, face, groin or armpit, although it is used on the skin in other areas of the body. Continue reading

Halobetasol can be applied to the skin to treat the redness, itching and swelling caused by poison ivy in patients 12 years of age and older. It is considered a super-high potency topical anti-inflammatory corticosteroid. It requires a prescription and comes as a cream, ointment, foam, or lotion. Generic and brand name products are available. Continue reading

Halobetasol should not be used on the face or for acne because it is a super-high potency topical corticosteroid. The skin on the face is quite thin compared with the skin on other areas of the body and using halobetasol on the face can increase the risk of acne and other side effects such as dryness, irritation, itching, redness, red or purple blotches underneath the skin, skin discoloration or thinning, small red or white bumps or a rash around the mouth, or unwanted hair growth. Continue reading

There is no limit on how long you can use Duobrii Lotion, but you should stop using it when your psoriasis has cleared and your doctor tells you to stop treatment. Once your skin is clear it may stay that way for up to 3 months after treatment. Continue reading

Even though Duobrii is a medicine used on the skin, it is highly potent. Excessive doses can pass through your skin and into your bloodstream, which may lead to serious side effects like suppression of your natural cortisol production, Cushing syndrome, high blood sugar or vision problems. Follow your doctor’s dosing instructions exactly. Continue reading

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.