Drug Interaction Report

Consumer information for this interaction is not currently available.

MONITOR CLOSELY: Concomitant use of landiolol and epinephrine may attenuate the response to epinephrine in the treatment of anaphylactic reactions. Some authorities suggest sensitivity and severity of allergic reactions, towards allergens, may be increased in patients taking beta-blockers alone and landiolol may reduce the response to usual doses of epinephrine. Additionally, epinephrine may reduce the therapeutic effects of landiolol. Coadministration with positive inotropes, vasoconstrictors, or sympathomimetic agents (e.g., epinephrine) may decrease landiolol's heart rate and blood pressure lowering effects.

MANAGEMENT : If coadministration is clinically necessary, careful titration of the landiolol infusion, dose adjustment of either agent to achieve the desired effect, and close hemodynamic monitoring are advised. Consultation with package labeling and relevant institutional protocols may be advisable for further guidance.

Both EPINEPHrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.