Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- diflunisal
- Lowsium Plus (magaldrate / simethicone)
Interactions between your drugs
diflunisal magaldrate
Applies to: diflunisal, Lowsium Plus (magaldrate / simethicone)
Concomitant administration of diflunisal and aluminum-containing products reduces the oral bioavailability of diflunisal by up to 40%. Doses of diflunisal and aluminum-containing products should be separated by at least 2 hours to ensure adequate absorption of diflunisal. Patients should be monitored for altered clinical effects of diflunisal.
References (3)
- D'Arcy PF, McElnay JC (1987) "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm, 21, p. 607-17
- Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, de Schepper PJ (1979) "Effect of aluminum hydroxide on diflunisal absorption." Br J Clin Pharmacol, 7, p. 519-22
- (2001) "Product Information. Dolobid (diflunisal)." Merck & Co., Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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