Drug Interaction Report

Encorafenib may decrease the blood levels and effects of medroxyPROGESTERone. You may need a dose adjustment if you have been taking medroxyPROGESTERone and are starting treatment with encorafenib. Contact your doctor if your condition changes during treatment with these medications. The interaction is not expected to occur if you are getting medroxyPROGESTERone by shot for birth control. However, let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of medroxyPROGESTERone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Encorafenib may reduce the blood levels and effects of conjugated estrogens. If you are using low-dose oral contraceptives, you may have an increased risk of breakthrough bleeding and unintended pregnancy. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You should preferably avoid consumption of grapefruit and grapefruit juice while taking encorafenib. Grapefruit and grapefruit juice can significantly increase the blood levels of encorafenib. This may increase the risk of serious side effects such as bleeding complications, eye and vision problems, liver problems, irregular heart rhythm, and development of new skin cancers. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Information for this minor interaction is available on the professional version.