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Generic Name: encorafenib (EN koe RAF e nib)
Brand Name: Braftovi

Medically reviewed by on Aug 23, 2018 – Written by Cerner Multum

What is encorafenib?

Encorafenib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Encorafenib is used in combination with another medicine called binimetinib (Mektovi) to treat melanoma (skin cancer) in people who have a "BRAF" gene mutation. These medicines are for use in treating melanoma that cannot be treated with surgery or has spread to other parts of the body.

Encorafenib may also be used for purposes not listed in this medication guide.

Important Information

Encorafenib can cause birth defects. Do not use if you are pregnant. Avoid getting pregnant while using encorafenib and for at least 2 weeks after your last dose.

Although encorafenib is used to treat melanoma, using encorafenib may increase your risk of developing other types of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms.

Before taking this medicine

You should not use encorafenib if you are allergic to it.

Tell your doctor if you have ever had:

  • heart disease, high blood pressure;

  • long QT syndrome (in you or a family member);

  • diabetes;

  • lung disease;

  • liver or kidney disease;

  • a muscle disorder;

  • eye problems (especially a problem with your retina); or

  • bleeding problems, or a blood clot.

Using encorafenib may increase your risk of developing a other types of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.

Do not use encorafenib if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.

You should not breast-feed while using this medicine, and for at least 3 days after your last dose.

How should I take encorafenib?

Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with encorafenib.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Encorafenib is usually taken once per day, with or without food.

Do not change your dose or dosing schedule without your doctor's advice.

Your doctor will need to check your skin every 2 months while you are using encorafenib, and for up to 6 months after your last dose.

If you vomit shortly after taking encorafenib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

You will need frequent medical tests.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking encorafenib?

Grapefruit may interact with encorafenib and lead to unwanted side effects. Avoid the use of grapefruit products.

encorafenib can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Encorafenib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects are more likely to occur if you take encorafenib and binimetinib together. Call your doctor at once if you have:

  • eye pain or swelling, vision changes, seeing halos around lights, seeing color "dots" in your vision;

  • severe skin rash, skin pain or swelling, redness and peeling skin on your hands or feet;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or

  • signs of bleeding--weakness, dizziness, headache, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, vomiting, stomach pain;

  • tiredness; or

  • joint pain or swelling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Encorafenib dosing information

Usual Adult Dose for Melanoma -- Metastatic:

450 mg orally once a day in combination with binimetinib until disease progression or unacceptable toxicity
NOTE: If binimetinib is withheld, reduce encorafenib to a maximum dose of 300 orally mg once a day until binimetinib is resumed.

-Confirm the presence of a BRAF V600E or V600K mutation in tumor specimens prior to initiating therapy.
-Refer to the binimetinib prescribing information for recommended dosing information.
-This drug may be taken with or without food.
-If a dose is missed, do not take it within 12 hours of the next dose.
-Do not take an additional dose if vomiting occurs after administration but continue with the next scheduled dose.

Use: In combination with binimetinib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test

What other drugs will affect encorafenib?

Other drugs may affect encorafenib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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