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Encorafenib Side Effects

Medically reviewed by Drugs.com. Last updated on July 15, 2020.

For the Consumer

Applies to encorafenib: oral capsule

Side effects requiring immediate medical attention

Along with its needed effects, encorafenib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking encorafenib:

More common

  • Bleeding gums
  • bloating
  • chills
  • constipation
  • coughing up blood
  • dark urine
  • difficulty in breathing or swallowing
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • hives, itching, skin rash
  • hoarseness
  • increased menstrual flow or vaginal bleeding
  • indigestion
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea
  • nosebleed
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • partial or slight paralysis of the face
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark-brown urine
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • swelling of the eyelids, face, lips, hands, or feet
  • thickening of the skin
  • tightness in the chest
  • tingling of the hands and feet
  • ulceration of the skin
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Rare

  • Black, tarry stools
  • bloody stools
  • vomiting of blood or material that looks like coffee grounds

Side effects not requiring immediate medical attention

Some side effects of encorafenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • burning, numbness, tingling, or painful sensations
  • change in taste
  • difficulty in moving
  • dry skin
  • hair loss, thinning of hair
  • loss of taste
  • muscular pain, tenderness, wasting, or weakness
  • pain in the arms or legs
  • stomach pain
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to encorafenib: oral capsule

Hematologic

Very common (10% or more): Anemia (36%), hemorrhage (19%), leukopenia (13%), lymphopenia (13%), neutropenia (13%)[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (46%), myopathy (23%), pain in extremity (11%), myalgia, back pain[Ref]

Ocular

Common (1% to 10%): Uveitis (e.g., iritis, iridocyclitis), visual impairment[Ref]

Metabolic

Very common (10% or more): Increased alkaline phosphatase (35%), hyperglycemia (28%), hypermagnesemia (26%), hyponatremia (18%), decreased appetite[Ref]

Hepatic

Very common (10% or more): Increased gamma glutamyl transferase (45%), increased ALT (29%), increased AST (27%)[Ref]

Oncologic

Common (1% to 10%): New primary melanoma, cutaneous squamous cell carcinoma (cuSCC) including keratoacanthoma (KA), basal cell carcinoma[Ref]

Other

Very common (10% or more): Pyrexia (30%), fatigue, peripheral edema[Ref]

Nervous system

Very common (10% or more): Fatigue (46%), headache (22%), dizziness (15%), peripheral neuropathy (12%), intracranial hemorrhage in the setting of new or progressive brain metastases (sometimes fatal)

Common (1% to 10%): Facial paresis, dysgeusia[Ref]

Renal

Very common (10% or more): Creatinine increased (93%)

Common (1% to 10%): Renal failure[Ref]

Cardiovascular

Very common (10% or more): Hypertension (e.g., pulmonary embolism, deep vein thrombosis, embolism, thrombophlebitis, thrombophlebitis superficial, thrombosis)

Uncommon (0.1% to 1%): QTc interval prolongation[Ref]

Dermatologic

Very common (10% or more): Rash (53%), hyperkeratosis (49%), alopecia (38%), dry skin (26%), pruritus (21%), skin papilloma (e.g., keratoacanthoma, squamous cell carcinoma, lip squamous cell carcinoma, squamous cell carcinoma of skin), melanocytic nevus

Common (1% to 10%): Panniculitis, new primary melanoma, basal cell carcinoma, skin papilloma, dermatitis acneiform, skin exfoliation, photosensitivity, panniculitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (41%), vomiting (30%), abdominal pain (28%), constipation (22%), diarrhea

Common (1% to 10%): GI hemorrhage (including rectal hemorrhage), hematochezia, hemorrhoidal hemorrhage, pancreatitis, colitis

Uncommon (0.1% to 1%): Pancreatitis[Ref]

Psychiatric

Very common (10% or more): Insomnia[Ref]

References

1. "Product Information. Braftovi (encorafenib)." Array BioPharma Inc., Boulder, CO.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.