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Drug Interaction Report

8 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

cloZAPine ethinyl estradiol

Applies to: clozapine, Loestrin 24 Fe (ethinyl estradiol / norethindrone)

Using cloZAPine together with ethinyl estradiol may increase the effects of cloZAPine. Contact your doctor if you experience confusion, fainting, fast heart rate, drowsiness, drooling, difficulty breathing, and seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cloZAPine norethindrone

Applies to: clozapine, Loestrin 24 Fe (ethinyl estradiol / norethindrone)

Using cloZAPine together with norethindrone may increase the effects of cloZAPine. Contact your doctor if you experience confusion, fainting, fast heart rate, drowsiness, drooling, difficulty breathing, and seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

cloZAPine food

Applies to: clozapine

Alcohol can increase the nervous system side effects of cloZAPine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloZAPine. Do not use more than the recommended dose of cloZAPine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

norethindrone food

Applies to: Loestrin 24 Fe (ethinyl estradiol / norethindrone)

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Minor

ethinyl estradiol food

Applies to: Loestrin 24 Fe (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Loestrin 24 Fe (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

norethindrone food

Applies to: Loestrin 24 Fe (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

cloZAPine food

Applies to: clozapine

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.