Drug Interaction Report

Talk to your doctor before using pexidartinib together with sodium bicarbonate. Sodium bicarbonate can interfere with the absorption of pexidartinib and reduce its effectiveness if they are taken too close together. In some cases, your doctor may want to prescribe alternatives that do not interact. Otherwise, you may be able to minimize the interaction by taking pexidartinib at least 2 hours before or 2 hours after sodium bicarbonate. Contact your doctor if your condition worsens during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You may experience reduced absorption of pexidartinib in the presence of food. Pexidartinib should be taken on an empty stomach at least 1 hour before or 2 hours after food. This will make it easier for your body to absorb the medication. Also, while taking pexidartinib, you should avoid grapefruits and grapefruit juice. Grapefruit and grapefruit juice can raise the levels of pexidartinib in your body and lead to potentially dangerous adverse effects. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.