Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Choledyl (oxtriphylline)
- sulfinpyrazone
Interactions between your drugs
sulfinpyrazone oxtriphylline
Applies to: sulfinpyrazone, Choledyl (oxtriphylline)
In one study, concomitant administration of sulfinpyrazone resulted in a 22% increase in total theophylline clearance. Changes noted in the elimination of theophylline included an increase in metabolism and a decrease in renal excretion. The clinical significance of this interaction is unknown. If sulfinpyrazone and theophylline are given together, clinical monitoring of patient response and serum theophylline levels is recommended. Patients should be advised to report worsening of their respiratory symptoms to their physician.
References (3)
- Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet, 20, p. 135-50
- Birkett DJ, Miners JO, Attwood J (1983) "Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline-sulphinpyrazone interactions." Br J Clin Pharmacol, 15, p. 567-9
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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