Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- nicotine
- thiotepa
Interactions between your drugs
nicotine thiotepa
Applies to: nicotine, thiotepa
Coadministration of thiotepa may increase plasma concentrations of drugs that are primarily metabolized by CYP450 2B6. Thiotepa has been shown to be a weak inhibitor of CYP450 2B6 in vitro, although drug interactions studies are not available, and the clinical significance is unknown. Product labeling for the specific CYP450 2B6 substrate should be consulted for additional recommendations and monitoring for increased adverse effects when used concomitantly with thiotepa may be warranted.
References (4)
- (2023) "Product Information. Thiotepa (thiotepa)." Meitheal Pharmaceuticals Inc.
- (2023) "Product Information. Tepadina (thiotepa)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 3
- (2022) "Product Information. Thiotepa (thiotepa)." MSN Laboratories Europe Ltd
- (2021) "Product Information. Tepadina (thiotepa)." Adienne SA
Drug and food interactions
nicotine food
Applies to: nicotine
One study (n=12) has reported that there was a significant interactive effect of caffeine and nicotine on subjective arousal such that nicotine decreased arousal only in the presence of caffeine. The exact mechanism of this interaction has not been specified. Further research is needed to examine the subjective and physiological interactions between caffeine and nicotine.
References (1)
- Rose JE, Behm FM (1991) "Psychophysiological interactions between caffeine and nicotine." Pharmacol Biochem Behav, 38, p. 333-7
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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