Drug Interaction Report

GENERALLY AVOID: The use of fenoldopam in combination with beta-blockers has not been studied. Theoretically, beta-blockers may potentiate the risk of severe, symptomatic hypotension by inhibiting the sympathetic reflex response to fenoldopam-induced blood pressure decreases.

MANAGEMENT: Concomitant use of fenoldopam with beta-blockers should be avoided if possible. The same precaution may be applicable to beta-blocker ophthalmic preparations, as they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels. Moreover, since fenoldopam may cause a dose-dependent increase in intraocular pressure, caution should be exercised if it is administered to patients with glaucoma or ocular hypertension receiving ophthalmic beta-blockers.