Drug Interaction Report

Leflunomide may cause liver problems, and using it with other medications that can also affect the liver such as acitretin may increase that risk. Because leflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Take acitretin with food. Women must avoid all drinks, food, and medicines (including over-the-counter products) that contain alcohol while taking acitretin or for 2 months after stopping treatment. Alcoholic beverages increase the risk for birth defects while taking acitretin. Acitretin can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy. Never use acitretin if you are pregnant. Both a primary and a secondary form of birth control must be used together and for at least 3 years after stopping therapy. Talk with your doctor about other possible birth control methods while you are taking acitretin. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Leflunomide can be taken with or without food. It is important to take leflunomide regularly to get the most benefit. Discuss with your doctor the use of alcohol while taking leflunomide. Alcohol and leflunomide can both be damaging to the liver.