Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Cerebyx (fosphenytoin)
- dofetilide
Interactions between your drugs
fosphenytoin dofetilide
Applies to: Cerebyx (fosphenytoin), dofetilide
Dofetilide is metabolized to a small extent by CYP450 3A4 microsomal enzymes in the liver. The clinician should be aware of the potential for an interaction when dofetilide is used in combination with another medication that induces CYP450 3A4. When concomitant therapy is required, the manufacturer recommends monitoring the patient for alterations in therapeutic effect. Dosage modifications may be necessary.
References (1)
- (2001) "Product Information. Tikosyn (dofetilide)." Pfizer U.S. Pharmaceuticals
Drug and food interactions
dofetilide food
Applies to: dofetilide
In vitro data suggest that grapefruit juice may inhibit the CYP450 3A4 first-pass metabolism of dofetilide. Decreased first-pass metabolism may increase dofetilide concentrations and increase the risk of QT interval prolongation and arrhythmias. The clinical significance is unknown, since dofetilide has a high oral bioavailability and a low affinity for CYP450 3A4. The manufacturer recommends caution.
References (1)
- (2001) "Product Information. Tikosyn (dofetilide)." Pfizer U.S. Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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