Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- fosphenytoin
- tretinoin
Interactions between your drugs
tretinoin fosphenytoin
Applies to: tretinoin, fosphenytoin
GENERALLY AVOID: Concomitant use of strong CYP450 3A4 inducers with tretinoin (systemic) may decrease the plasma concentration of tretinoin, which is a CYP450 3A4 substrate. Reduced efficacy of tretinoin may occur. Studies document the interaction between endogenous retinoids and CYP450 3A4 inducers (e.g., carbamazepine, phenytoin, phenobarbital) showing decreased concentration of the retinoids and reduced efficacy. While clinical data specific to tretinoin are not available, similar effects may occur.
MANAGEMENT: The manufacturer recommends avoiding concomitant use of tretinoin with strong CYP450 3A4 inducers due to a potentially significant reduction in its efficacy.
References (8)
- (2023) "Product Information. Jamp Tretinoin (tretinoin)." Jamp Pharma Corporation
- (2023) "Product Information. Vesanoid (tretinoin)." Neon Healthcare Ltd
- fex g, larsson k, andersson a, Berggren-Soderlund M (1995) "Low serum concentration of all-trans and 13-cis retinoic acids in patients treated with phenytoin, carbamazepine and valproate. Possible relation to teratogenicity" Arch Toxicol, 69, p. 572-74
- nau h, tzimas g, mondry m, plum c, spohr hl (1995) "Antiepileptic drugs alter endogenous retinoid concentrations: a possible mechanism of teratogenesis of anticonvulsant therapy" Life Sci, 57, p. 53-60
- (2024) "Product Information. Vesanoid (tretinoin)." H2-Pharma LLC
- (2024) "Product Information. Vesanoid (tretinoin)." Pharmaco Australia Ltd
- (2022) "Product Information. Vesanoid (tretinoin)." Xediton Pharmaceuticals Inc
- (2023) "Product Information. VESANOID (tretinoína)." CHEPLAPHARM ARZNEIMITTEL GMBH
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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