Skip to main content

How do I use opioid pain medications safely?

By Melody L. Berg PharmD, BCPS, MPH

Medically reviewed by Carmen Pope, BPharm. Last updated on March 12, 2025.

Stories abound lately in the news about what is being called an epidemic of opioid medication addiction in the U.S. If a doctor has ever prescribed this type of painkiller for you, it's important to understand how to take it safely and effectively while minimizing the risk of side effects or addiction. Below are some answers to commonly asked questions about opioid medications.

What are opioids?

Opioids are a class of prescription pain medications related to morphine. Opioids include codeine, fentanyl, hydrocodone, hydromorphone, methadone, and oxycodone.

Opioid medicines are useful for acute pain, such as the pain experienced during or after surgery or the pain associated with advanced cancer. Opioids may also be used to treat severe chronic pain that has not been controlled by nonopioid treatments. However, studies have not yet been done to determine whether opioids control chronic pain well when used in the long term. Although opioids can be highly effective in the treatment of severe pain, it's important to understand that they can have unwanted side effects and may lead to addiction.

Why should I be concerned?

According to the Centers for Disease Control and Prevention (CDC), more deaths occur as a result of opioid overdose than all other drug overdoses combined, including cocaine and heroin. In fact, from 1999 to 2014, more than 165,000 Americans have died from overdoses involving prescription opioids.

Addiction is patient-specific. It can happen quickly or over time, as each individual has inherent risk factors for possible addiction. If you or your family has a history of abuse, be sure to discuss this with your healthcare provider before taking any opioids.

What do I need to know about opioids?

Follow the steps below to stay safe and protect your loved ones:

Related questions

Where can I find more information about opioid addiction?

Many resources are available about the safe use of opioids and to assist people who struggle with substance abuse, including the following:

See also:

Related medical questions

Drug information

Related support groups

ASHP logo

AHFS® Patient Medication Information is used with permission. ©2025, the American Society of Health-System Pharmacists, Inc. (ASHP). The ASHP Data is a part of the AHFS Drug Information®️; ASHP is not responsible for the accuracy of transpositions from the original context.