Pronunciation: Im-poise
Generic name: clobetasol propionate 0.025%
Brand name: Impoyz
Dosage form: cream
Drug class: Topical steroids

Medically reviewed by Carmen Pope, BPharm. Last updated on May 16, 2024.

What is Impoyz cream?

Impoyz cream is a highly potent topical steroid that may be applied to the skin to reduce inflammation and itching caused by moderate to severe plaque psoriasis in adults aged 18 years and older. It contains clobetasol propionate 0.025% and should not be used for longer than 2 weeks.

Impoyz cream is specially formulated using an ingredient called Transcutol that enhances the solubility of clobetasol and its permeation into plaques. This means that Impoyz is just as effective as other clobetasol creams but with half the usual concentration of clobetasol, which decreases its risk of side effects including absorption into the bloodstream. Transcutol is also less disrupting to the skin’s lamellar structure (a layer of lipids and water in the stratum corneum) than propylene glycol, which is traditionally used in creams to enhance drug solubility.

Impoyz was FDA approved on December 1, 2017.

Warnings

Impoyz cream contains clobetasol propionate which can be absorbed through the skin into the bloodstream and cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency, including Cushing’s syndrome, hyperglycemia, and glucosuria. Do not use for longer than 2 weeks and do not exceed the recommended dose. Periodic monitoring for HPA suppression may be required.

Occlusive dressings should not be used unless under the advice of the doctor because these increase the risk of side effects.

Before taking this medicine

You should not use Impoyz if you are allergic to it.

Tell your doctor if you have ever had:

• any type of skin infection;
• a skin reaction to any steroid medicine;
• liver disease; or
• an adrenal gland disorder.

Topical corticosteroids can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.

Children are more susceptible to systemic absorption of topical corticosteroids and Impoyz is not for use in children or young adults under the age of 18.

It is not known whether Impoyz will harm an unborn baby. Tell your doctor if you are pregnant. If you are instructed to use Impoyz cream, use only a small amount and for the shortest time possible.

It may not be safe to breastfeed while using this medicine. If you are instructed to use Impoyz cream, use only a small amount and for the shortest time possible. Do not apply to the breasts.

How do I use Impoyz cream?

Apply a thin layer of Impoyz to the affected areas twice a day. Rub in gently and completely. Apply exactly as directed.

• Wash your hands after applying.
• Stop using Impoyz cream when your psoriasis is controlled but do not use it for longer than 2 weeks. If 2 weeks have passed and your psoriasis has not got any better, stop applying the cream and contact your doctor.
• If your psoriasis gets better earlier than 2 weeks, stop using Impoyz.
• Do not exceed 50g per week.
• Do not use it if your skin is thin where you want to apply it.
• Do not bandage, cover, or wrap your skin where you have applied Impoyz unless your doctor has told you to do so.
• Do not use it on your face, scalp, armpits, groin, or skin folds.
• Do not use other corticosteroid products while using Impoyz.

Impoyz should only be applied to the skin. Do not take by mouth, apply near your eyes, or insert it.

What are the side effects of Impoyz cream?

The most common side effect of Impoyz Cream includes discoloration of the skin where you have applied it.

Topical corticosteroids can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency.

Other side effects reported with topical corticosteroids include:

• acne
• allergic contact dermatitis
• burning, itching, swelling, or irritation of treated skin
• dry or cracking skin
• redness or crusting around your hair follicles
• spider veins
• stretch marks, thinning skin
• rash or hives
• temporary hair loss.

If you develop a skin infection while using Impoyz your doctor may give you an antimicrobial cream to use as well. If this does not resolve the infection, your doctor may discontinue Impoyz until the infection has cleared.

Possible signs that you may be absorbing this medicine through your skin include weight gain in your face and shoulders, increased body hair, tiredness, mood changes, menstrual changes, and sexual changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

What other drugs will affect Impoyz?

Creams applied to the skin such as Impoyz are not likely to be affected by other drugs you use. But you should not use Impoyz with other topical or oral corticosteroids, because they may have an additive effect.

Tell your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Ingredients

Active ingredients: clobetasol propionate 0.25mg in 1g of cream base (equivalent to 0.025%).

The cream base contains diethylene glycol monoethyl ether (Transcutol), butylated hydroxytoluene, cetostearyl alcohol, cyclomethicone, glyceryl stearate, and PEG 100 stearate, isopropyl myristate, methyl paraben, propylparaben, purified water, and white wax.

Supplied in 60-gram and 112 gram aluminum tubes.

Storage

Store at room temperature 20°C – 25°C (68°F – 77°F). Do not freeze.

Manufacturer

Primus Pharmaceuticals, Inc.

Popular FAQ

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